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dc.contributor.author
Talevi, Alan
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dc.contributor.other
Talevi, Alan
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dc.contributor.other
Rocha Arrieta, Luisa Lilia
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dc.date.available
2020-09-22T20:40:05Z
dc.date.issued
2016
dc.identifier.citation
Talevi, Alan; The importance of drug repurposing in the field of antiepileptic drug development; Springer; 2016; 365-377
dc.identifier.isbn
978-1-4939-6355-9
dc.identifier.uri
http://hdl.handle.net/11336/114582
dc.description.abstract
Drug repurposing involves finding new therapeutic uses for existing drugs, including marketed, discontinued, shelved, and investigational drugs. The advantages of this strategy are many: reduced drug development timeline, best chances of surviving Phase II and Phase III clinical trials, simplified dosage form development, and, of course, added value to drugs belonging to a company or laboratory portfolio. The relatively high number of antiepileptic drugs which have been successfully repurposed and the fact that many drugs from other categories have proven anticonvulsant effects at the preclinical and even clinical level suggest that this strategy should be widely exploited in the antiepileptic drug discovery field. Here, we present an overview of the current approaches to drug repurposing, along with practical considerations to face a drug repurposing campaign to find new treatments for epilepsy and novel therapeutic uses for antiepileptic drugs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
COMPUTER-GUIDED DRUG REPURPOSING
dc.subject
DRUG REPOSITIONING
dc.subject
DRUG REPROFILING
dc.subject
DRUG REPURPOSING
dc.subject
DRUG RESCUE
dc.subject
EPILEPSY
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INDICATION EXPANSION
dc.subject
INDICATION SHIFT
dc.subject
IN SILICO DRUG REPURPOSING
dc.subject
OFF-LABEL USE
dc.subject.classification
Otras Ciencias Químicas
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
The importance of drug repurposing in the field of antiepileptic drug development
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2020-08-19T20:27:42Z
dc.journal.pagination
365-377
dc.journal.pais
Alemania
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dc.description.fil
Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/978-1-4939-6355-3_19
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/protocol/10.1007%2F978-1-4939-6355-3_19
dc.conicet.paginas
387
dc.source.titulo
Antiepileptic drug discovery: Novel approaches
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