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dc.contributor.author
Talevi, Alan

dc.contributor.other
Talevi, Alan

dc.contributor.other
Rocha, Luis
dc.date.available
2020-09-22T20:28:25Z
dc.date.issued
2016
dc.identifier.citation
Talevi, Alan; Network pharmacology and epilepsy; Springer; 2016; 351-364
dc.identifier.isbn
978-1-4939-6355-9
dc.identifier.uri
http://hdl.handle.net/11336/114576
dc.description.abstract
In contrast with the reductionist “one gene, one target, one drug” approach, network pharmacology proposes the use of multi-target therapies, a strategy that seems particularly suitable to treat disorders of complex etiology, among them epilepsy. As a matter of fact, most of the existing antiepileptic drugs are indeed multi-target unintended agents. Whereas a number of authors have recently advocated the use of network-based approximations in the antiepileptic drug discovery fi eld, such strategy has so far not produced deliverables. Here, we review some practical considerations which could be used to assist in silico and wet screening for novel antiepileptic agents.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer

dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
EPILEPSY
dc.subject
NETWORK PHARMACOLOGY
dc.subject
SYSTEMS BIOLOGY
dc.subject
MULTI-TARGET DRUG
dc.subject
TAILORED MULTI-TARGET DRUG
dc.subject.classification
Farmacología y Farmacia

dc.subject.classification
Medicina Básica

dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD

dc.title
Network pharmacology and epilepsy
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2020-08-19T20:27:36Z
dc.journal.pagination
351-364
dc.journal.pais
Alemania

dc.description.fil
Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/978-1-4939-6355-3_18
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/protocol/10.1007%2F978-1-4939-6355-3_18
dc.conicet.paginas
387
dc.source.titulo
Antiepileptic drug discovery: Novel approaches
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