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Artículo

Determination of loratadine and pseudoephedrine sulfate in pharmaceuticals based on non-linear second-order spectrophotometric data generated by a pH-gradient flow injection technique and artificial neural networks

Culzoni, Maria JuliaIcon ; Goicoechea, Hector CasimiroIcon
Fecha de publicación: 12/2007
Editorial: Springer Heidelberg
Revista: Analytical and Bioanalytical Chemistry
ISSN: 1618-2642
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Química Analítica

Resumen

Loratadine (LOR) and pseudoephedrine sulfate (PES) were determined in pharmaceutical samples by using non-linear second-order data generated by a pH-gradient flow injection analysis (FIA) system with diode-array detection. Determination of both analytes was performed on the basis of differences between the acid-base and spectral features of each drug species. Non-linearities were detected by using both qualitative and quantitative tools. As a consequence of the non-linearity, a recently reported algorithm, artificial neural networks followed by residual bilinearization (ANN/RBL), was shown to furnish more satisfactory results. Recoveries of 99.7% (LOR) and 95.6% (PES) were obtained when analyzing a validation set containing unexpected components (the usual excipients found in pharmaceutical preparations). The average value obtained by implementation of the method on four replicates was compared with that obtained by a reference method based on HPLC (difference not significant; p > 0.05).
Palabras clave: ARTIFICIAL NEURAL NETWORKS , LORATADINE , PHARMACEUTICAL , PSEUDOEPHEDRINE , SECOND-ORDER ADVANTAGE
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/114395
URL: https://link.springer.com/article/10.1007/s00216-007-1656-6
DOI: http://dx.doi.org/10.1007/s00216-007-1656-6
Colecciones
Articulos(CCT - SANTA FE)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SANTA FE
Articulos(IQUIR)
Articulos de INST.DE QUIMICA ROSARIO
Citación
Culzoni, Maria Julia; Goicoechea, Hector Casimiro; Determination of loratadine and pseudoephedrine sulfate in pharmaceuticals based on non-linear second-order spectrophotometric data generated by a pH-gradient flow injection technique and artificial neural networks; Springer Heidelberg; Analytical and Bioanalytical Chemistry; 389; 7-8; 12-2007; 2217-2225
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