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dc.contributor.author
Baravalle, Celina  
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Salvetti, Natalia Raquel  
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Mira, G. A.  
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Lorente, J. A.  
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Ortega, Hugo Hector  
dc.date.available
2020-09-21T12:06:18Z  
dc.date.issued
2007-12  
dc.identifier.citation
Baravalle, Celina; Salvetti, Natalia Raquel; Mira, G. A.; Lorente, J. A.; Ortega, Hugo Hector; The role of ACTH in the pathogenesis of Polycystic Ovarian Syndrome in the rat: hormonal profiles and ovarian morphology.; Acad Sciences Czech Republic; Physiological Research; 56; 12-2007; 67-78  
dc.identifier.issn
0862-8408  
dc.identifier.uri
http://hdl.handle.net/11336/114384  
dc.description.abstract
Numerous hypotheses have been proposed about the pathogenia of the polycystic ovarian syndrome (PCOS). However, hormonal control of the persistent follicle has not been established. The objective of the present study was to compare the follicular structure and hormonal profiles of rats treated with adrenocorticotrophic hormone (ACTH) with two experimental models of PCOS. ACTH-treated animals were compared with those exposed to continuous light, treated with estradiol valerate, and control (in proestrous and diestrous). Serum hormone levels, histomorphometrical changes, and immunoexpression of vimentin, cytokeratins, cadherins, and proliferating cell nuclear antigen (PCNA) were examined. Treatment with ACTH resulted in an elevation of corticosterone secretion with LH reduction but without changes in ovarian morphology. Although stress (or ACTH) stimulation may be only one pathophysiological mechanism involved in follicular cyst pathogenia in other species, we do not find important evidence to suppose that this would happen in rats.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Acad Sciences Czech Republic  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
PCOD  
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rat  
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ACTH  
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proliferation  
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Ciencias Veterinarias  
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Ciencias Veterinarias  
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CIENCIAS AGRÍCOLAS  
dc.title
The role of ACTH in the pathogenesis of Polycystic Ovarian Syndrome in the rat: hormonal profiles and ovarian morphology.  
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info:eu-repo/semantics/article  
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info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-09-03T19:24:34Z  
dc.journal.volume
56  
dc.journal.pagination
67-78  
dc.journal.pais
República Checa  
dc.description.fil
Fil: Baravalle, Celina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Salvetti, Natalia Raquel. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Mira, G. A.. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina  
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Fil: Lorente, J. A.. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina  
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Fil: Ortega, Hugo Hector. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
Physiological Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.biomed.cas.cz/physiolres/pdf/56/56_67.pdf