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dc.contributor.author
Montoya, Alba  
dc.contributor.author
Quiroga, Jairo  
dc.contributor.author
Abonia, Rodrigo  
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Derita, Marcos Gabriel  
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Sortino, Maximiliano Andrés  
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Ornelas, Alfredo  
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Zacchino, Susana Alicia Stella  
dc.contributor.author
Insuasty, Braulio  
dc.date.available
2020-09-16T21:02:55Z  
dc.date.issued
2016-08  
dc.identifier.citation
Montoya, Alba; Quiroga, Jairo; Abonia, Rodrigo; Derita, Marcos Gabriel; Sortino, Maximiliano Andrés; et al.; Hybrid Molecules Containing a 7-Chloro-4-aminoquinoline Nucleus and a Substituted 2-Pyrazoline with Antiproliferative and Antifungal Activity; Molecular Diversity Preservation International; Molecules; 21; 8; 8-2016; 969-988  
dc.identifier.issn
1420-3049  
dc.identifier.uri
http://hdl.handle.net/11336/114168  
dc.description.abstract
Twenty-four new hybrid analogues (15-38) containing 7-chloro-4-aminoquinoline and 2-pyrazoline N-heterocyclic fragments were synthesized. Twelve of the new compounds were evaluated against 58 human cancer cell lines by the U.S. National Cancer Institute (NCI). Compounds 25, 30, 31, 36, and 37 showed significant cytostatic activity, with the most outstanding GI50 values ranging from 0.05 to 0.95 μM. The hybrid compounds (15-38) were also evaluated for antifungal activity against Candida albicans and Cryptococcus neoformans. From the obtained results some structure-activity relationships were outlined.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Molecular Diversity Preservation International  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
ANTIFUNGAL  
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ANTIPROLIFERATIVE ACTIVITY  
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CHALCONES  
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CYCLOCONDENSATION REACTION  
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N-ARYL-2-PYRAZOLINES  
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Química Orgánica  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Hybrid Molecules Containing a 7-Chloro-4-aminoquinoline Nucleus and a Substituted 2-Pyrazoline with Antiproliferative and Antifungal Activity  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-08-05T16:40:49Z  
dc.journal.volume
21  
dc.journal.number
8  
dc.journal.pagination
969-988  
dc.journal.pais
Suiza  
dc.journal.ciudad
Basilea  
dc.description.fil
Fil: Montoya, Alba. Universidad del Valle; Colombia  
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Fil: Quiroga, Jairo. Universidad del Valle; Colombia  
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Fil: Abonia, Rodrigo. Universidad del Valle; Colombia  
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Fil: Derita, Marcos Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina  
dc.description.fil
Fil: Sortino, Maximiliano Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina  
dc.description.fil
Fil: Ornelas, Alfredo. University of Texas at El Paso; Estados Unidos  
dc.description.fil
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina  
dc.description.fil
Fil: Insuasty, Braulio. Universidad del Valle; Colombia  
dc.journal.title
Molecules  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/molecules21080969  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/21/8/969  

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