Mostrar el registro sencillo del ítem
dc.contributor.author
Russo, María Julieta
dc.contributor.author
Cohen, Gabriela
dc.contributor.author
Chrem Mendez, Patricio Alexis
dc.contributor.author
Campos, Jorge
dc.contributor.author
Nahas, Federico Exequiel
dc.contributor.author
Surace, Ezequiel Ignacio
dc.contributor.author
Vazquez, Silvia
dc.contributor.author
Gustafson, Deborah
dc.contributor.author
Guinjoan, Salvador Martín
dc.contributor.author
Allegri, Ricardo Francisco
dc.contributor.author
Sevlever, Gustavo
dc.date.available
2020-09-15T20:56:22Z
dc.date.issued
2016-09
dc.identifier.citation
Russo, María Julieta; Cohen, Gabriela; Chrem Mendez, Patricio Alexis; Campos, Jorge; Nahas, Federico Exequiel; et al.; Predicting episodic memory performance using different biomarkers: Results from Argentina-Alzheimer’s disease neuroimaging initiative; Dove Press; Neuropsychiatric Disease and Treatment; 12; 9-2016; 2199-2206
dc.identifier.uri
http://hdl.handle.net/11336/114061
dc.description.abstract
Purpose: Argentina-Alzheimer’s Disease Neuroimaging Initiative (Arg-ADNI) is the first ADNI study to be performed in Latin America at a medical center with the appropriate infrastructure. Our objective was to describe baseline characteristics and to examine whether biomarkers related to Alzheimer’s disease (AD) physiopathology were associated with worse memory performance. Patients and methods: Fifteen controls and 28 mild cognitive impairment and 13 AD dementia subjects were included. For Arg-ADNI, all biomarker parameters and neuropsychological tests of ADNI-II were adopted. Results of positron emission tomography (PET) with fluorodeoxyglucose and11C-Pittsburgh compound-B (PIB-PET) were available from all participants. Cerebrospinal fluid biomarker results were available from 39 subjects. Results: A total of 56 participants were included and underwent baseline evaluation. The three groups were similar with respect to years of education and sex, and they differed in age (F=5.10, P=0.01). Mean scores for the baseline measurements of the neuropsychological evaluation differed significantly among the three groups at P<0.001, showing a continuum in their neuropsychological performance. No significant correlations were found between the principal measures (long-delay recall, C-Pittsburgh compound-B scan, left hippocampal volume, and APOEε4) and either age, sex, or education (P>0.1). Baseline amyloid deposition and left hippocampal volume separated the three diagnostic groups and correlated with the memory performance (P<0.001). Conclusion: Cross-sectional analysis of baseline data revealed links between cognition, structural changes, and biomarkers. Follow-up of a larger and more representative cohort, particularly analyzing cerebrospinal fluid and brain biomarkers, will allow better characterization of AD in our country.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Dove Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
AGING
dc.subject
ALZHEIMER´S DISEASE
dc.subject
AMYLOID IMAGING
dc.subject
BIOMARKERS
dc.subject
MILD COGNITIVE IMPAIRMENT
dc.subject.classification
Neurología Clínica
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Predicting episodic memory performance using different biomarkers: Results from Argentina-Alzheimer’s disease neuroimaging initiative
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-09-08T14:01:38Z
dc.identifier.eissn
1178-2021
dc.journal.volume
12
dc.journal.pagination
2199-2206
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Russo, María Julieta. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.description.fil
Fil: Cohen, Gabriela. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.description.fil
Fil: Chrem Mendez, Patricio Alexis. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.description.fil
Fil: Campos, Jorge. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.description.fil
Fil: Nahas, Federico Exequiel. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Surace, Ezequiel Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.description.fil
Fil: Vazquez, Silvia. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.description.fil
Fil: Gustafson, Deborah. University of New York; Estados Unidos
dc.description.fil
Fil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.description.fil
Fil: Allegri, Ricardo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.description.fil
Fil: Sevlever, Gustavo. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.journal.title
Neuropsychiatric Disease and Treatment
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.dovepress.com/predicting-episodic-memory-performance-using-different-biomarkers-resu-peer-reviewed-article-NDT
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2147/NDT.S107051
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028172/
Archivos asociados