Mostrar el registro sencillo del ítem

dc.contributor.author
Garcia, Nestor Horacio  
dc.contributor.author
Pérez, H. A.  
dc.contributor.author
Spence, J. D.  
dc.contributor.author
Armando, L. J.  
dc.date.available
2017-01-16T19:08:34Z  
dc.date.issued
2014-12  
dc.identifier.citation
Garcia, Nestor Horacio; Pérez, H. A.; Spence, J. D.; Armando, L. J.; Risk of vascular disease in premenopausal women with diabetes mellitus; Elsevier Science; Clinical Therapeutics; 36; 12; 12-2014; 1924–1934  
dc.identifier.issn
0149-2918  
dc.identifier.uri
http://hdl.handle.net/11336/11405  
dc.description.abstract
Purpose: The aims of this study were (1) to estimate the prevalence of cardiovascular disease risk factors among premenopausal and menopausal Argentinean women with and without type 2 diabetes mellitus and (2) to assess the contribution of total plaque area (TPA) to risk stratification when added to Framingham risk scores. Methods: A descriptive cross-sectional study in primary prevention in 1257 women (ages 19-84 years) from Argentina. TPA was measured by ultrasonography. Framingham sex-specific risk equations were used to predict the risk of developing cardiovascular disease, coronary heart disease, and stroke during the next 10 years. Patients were divided into diabetic (n = 293) and control groups (n = 964), and then each group was divided according to age (>40, 40–49, 50–59, and ≥60 years). Findings: No difference was observed between diabetic and control groups in the incidence of smoking or the presence of early family cardiovascular event. Overall, diabetic patients had higher body mass index, blood pressure, and TPA versus the control group. The Framingham risk score was higher in the diabetic group in all age groups. The mean (SD) coronary heart disease scores for the diabetic group at <40, 40 to 49, 50 to 59, and ≥60 were 6% (1.7%), 19% (2.5%), 38% (2.0%), and 60% (1.5%), respectively, whereas the scores in the control group 3% (0.8%), 7% (0.9%), 17% (0.9%), and 40% (0.9%), respectively. The stroke score was also enhanced in diabetic women, independent of their age. These data indicate that diabetic women in the premenopausal age or the early years of menopause age (40-50 years) are at intermediate or higher risk of developing a cardiovascular event. Implications: Premenopausal diabetic women should be considered at possibly high risk of cardiovascular events compared with nondiabetic women. Direct assessment of atherosclerotic burden, such as TPA, should be used early in this population instead of relying on traditional risk scores.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
Diabetes Mellitus  
dc.subject
Subclinical Atherosclerosis  
dc.subject
Cardiovascular Disease  
dc.subject
Women  
dc.subject.classification
Sistemas Cardíaco y Cardiovascular  
dc.subject.classification
Medicina Clínica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Risk of vascular disease in premenopausal women with diabetes mellitus  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-01-13T19:47:10Z  
dc.journal.volume
36  
dc.journal.number
12  
dc.journal.pagination
1924–1934  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Garcia, Nestor Horacio. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina  
dc.description.fil
Fil: Pérez, H. A.. Blossom DMO; Argentina  
dc.description.fil
Fil: Spence, J. D.. Western University; Canadá  
dc.description.fil
Fil: Armando, L. J.. Blossom DMO; Argentina  
dc.journal.title
Clinical Therapeutics  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.clinthera.2014.06.011  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0149291814003749