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dc.contributor.author
Cuestas, Eduardo
dc.contributor.author
Gaido, Maria Isabel
dc.contributor.author
Capra, Raul Horacio
dc.date.available
2017-01-16T19:01:18Z
dc.date.issued
2015-04
dc.identifier.citation
Cuestas, Eduardo; Gaido, Maria Isabel; Capra, Raul Horacio; Transient neonatal hyperthyrotropinemia is a risk factor for developing persistent hyperthyrotropinemia in childhood with repercussion on developmental status; Bioscientifica; European Journal Of Endocrinology; 172; 4; 4-2015; 483-490
dc.identifier.issn
0804-4643
dc.identifier.uri
http://hdl.handle.net/11336/11402
dc.description.abstract
Objective: Transient neonatal hyperthyrotropinemia (TNH) is defined as a neonatal abnormality of thyroid function, which reverts to normal at re-examination after 2 weeks of life. The thyroid function of these infants has not been sufficiently studied in terms of the risk of developing persistent hyperthyrotropinemia (PH) in later childhood and its impact on growth and development.
Design: A prospective cohort study included all babies born in our hospital between 2001 and 2006 and screened for hypothyroidism, whose thyroid function was re-examined 6 years later. Exclusion criteria included the following conditions: preterm birth, birth weight <2500 g, Down's syndrome, descendants of mothers with immune thyroid disease, congenital malformations, cardiac, renal, hepatic, and metabolic diseases, and steroid or dopamine medication. The variables included are TSH and thyroxine at neonatal screening and 6 years later. Main outcomes are the risk of developing PH in childhood, linear growth, and development using Parents' Evaluation of Developmental Status (PEDS).
Results: Out of 5040 normal-term newborns, 301 (6.0%, 95% CI 5.3–6.6%) have TSH ≥10 mU/l (TNH). Six years later, we re-examined 65 randomly selected children with TNH and 185 controls. In the TNH cohort, we found six out of 65 children (9.2%, 95% CI 1.4–17.0%) with PH (TSH ≥6.4 mU/l), and three out of 185 (1.6%, 95% CI 0.3–4.7%) among controls, relative risk 5.7 (95% CI 1.5–22.1), P=0.0114. TSH and developmental delay were found to be significantly higher in the TNH cohort (4.7±1.3 mU/l vs 2.1±0.5 mU/l, P<0.0001 and 15/65 (23%, 95% CI 12–34.1) vs 21/185 (11.3%, 95% CI 6.5–16.2) P=0.0348).
Conclusions: Newborns with TNH have a higher risk of developing PH in childhood, with repercussion on developmental status.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bioscientifica
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Transient Neonatal Hyperthyrotropinemia
dc.subject
Persistent Hyperthyrotropinemia
dc.subject
Developmental Status
dc.subject.classification
Pediatría
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Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Transient neonatal hyperthyrotropinemia is a risk factor for developing persistent hyperthyrotropinemia in childhood with repercussion on developmental status
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-01-13T19:40:55Z
dc.identifier.eissn
1479-683X
dc.journal.volume
172
dc.journal.number
4
dc.journal.pagination
483-490
dc.journal.pais
Reino Unido
dc.journal.ciudad
London
dc.description.fil
Fil: Cuestas, Eduardo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Hospital Privado - Centro Medico de Cba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Gaido, Maria Isabel. Hospital Privado - Centro Medico de Cba; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas; Argentina
dc.description.fil
Fil: Capra, Raul Horacio. Hospital Privado - Centro Medico de Cba; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas; Argentina
dc.journal.title
European Journal Of Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1530/EJE-13-0907
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.eje-online.org/content/172/4/483
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