Artículo

Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis

Garcia, Elizabeth AndreaIcon ; Bianco, María Verónica; Blanco, Federico CarlosIcon ; Bigi, FabianaIcon
Fecha de publicación: 08/2016
Editorial: Journal of Infection in Developing Countries
Revista: Journal of Infection in Developing Countries
ISSN: 2036-6590
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Mycobacterium bovis (Mb), the causative agent of bovine tuberculosis (bTB), infects cattle and other animals, including humans. In this study we found that a M. bovis knockout strain in phoP and mce2 operons protected C57BL/6 mice against virulent M. bovis challenge. The double mutant was significantly more attenuated than the parental M. bovis Δmce2 strain in immunodeficient mice.
Palabras clave: BOVINE TUBERCULOSIS , C57BL/6 MICE , LIVE VACCINE
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/113964
DOI: http://dx.doi.org/10.3855/jidc.7721
URL: https://jidc.org/index.php/journal/article/view/27580338
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Citación
Garcia, Elizabeth Andrea; Bianco, María Verónica; Blanco, Federico Carlos; Bigi, Fabiana; Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis; Journal of Infection in Developing Countries; Journal of Infection in Developing Countries; 10; 8; 8-2016; 892-894
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