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dc.contributor.author
Santamaría, Clarisa Guillermina
dc.contributor.author
Meyer, Nicole
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Schumacher, Anne
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Zenclussen, Maria Laura
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Teglia, Carla Mariela
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Culzoni, Maria Julia
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Zenclussen, Ana Claudia
dc.contributor.author
Rodriguez, Horacio Adolfo
dc.date.available
2020-09-14T11:52:37Z
dc.date.issued
2020-05
dc.identifier.citation
Santamaría, Clarisa Guillermina; Meyer, Nicole; Schumacher, Anne; Zenclussen, Maria Laura; Teglia, Carla Mariela; et al.; Dermal exposure to the UV filter benzophenone-3 during early pregnancy affects fetal growth and sex ratio of the progeny in mice; Springer; Archives of Toxicology; 94; 8; 5-2020; 2847-2859
dc.identifier.issn
0340-5761
dc.identifier.uri
http://hdl.handle.net/11336/113873
dc.description.abstract
The aim of this study was to analyze whether dermal exposure to benzophenone 3 (BP-3) during pregnancy affects criticalparameters of pregnancy, and whether this exposure may affect the outcome of a second pregnancy in mice. Pregnant micewere exposed to 50-mg BP-3/kg body weight/day or olive oil (vehicle) from gestation day (gd) 0 to gd6 by dermal exposure.High-frequency ultrasound imaging was used to follow up fetal and placental growth in vivo. Blood flow parameters inuterine and umbilical arteries were analyzed by Doppler measurements. Mice were killed at gd5, gd10, and gd14 on the firstpregnancy, and at gd10 and 14 on the second pregnancy. The weight of the first and second progenies was recorded, and sexratio was analyzed. BP-3 levels were analyzed in serum and amniotic fluid. BP-3 reduced the fetal weight at gd14 and fetoplacentaindex of first pregnancy, with 16.13% of fetuses under the 5th percentile; arteria uterina parameters showed alteredpattern at gd10. BP-3 was detected in serum 4 h after the exposure at gd6, and in amniotic fluid at gd14. Offspring weightof first progeny was lower in BP-3 group. Placenta weights of BP-3 group were decreased in second pregnancy. First andsecond progenies of mothers exposed to BP-3 showed a higher percentage of females (female sex ratio). Dermal exposureto low dose of BP-3 during early pregnancy resulted in an intrauterine growth restriction (IUGR) phenotype, disturbed sexratio and alterations in the growth curve of the offspring in mouse model.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Benzophenone-3
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Pregnancy
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Placenta
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Development
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Sex ratio
dc.subject.classification
Biología Reproductiva
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Dermal exposure to the UV filter benzophenone-3 during early pregnancy affects fetal growth and sex ratio of the progeny in mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-09-03T19:19:44Z
dc.journal.volume
94
dc.journal.number
8
dc.journal.pagination
2847-2859
dc.journal.pais
Alemania
dc.journal.ciudad
Berlin
dc.description.fil
Fil: Santamaría, Clarisa Guillermina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
dc.description.fil
Fil: Meyer, Nicole. Otto-von-Guericke-Universität Magdeburg; Alemania
dc.description.fil
Fil: Schumacher, Anne. Otto-von-Guericke-Universität Magdeburg; Alemania
dc.description.fil
Fil: Zenclussen, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
dc.description.fil
Fil: Teglia, Carla Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
dc.description.fil
Fil: Culzoni, Maria Julia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Zenclussen, Ana Claudia. Otto-von-Guericke-Universität Magdeburg; Alemania
dc.description.fil
Fil: Rodriguez, Horacio Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
dc.journal.title
Archives of Toxicology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/10.1007/s00204-020-02776-5
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00204-020-02776-5
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