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dc.contributor.author Carpentieri, Agata Rita
dc.contributor.author Oliva, Clara
dc.contributor.author Diez Noguera, Antoni
dc.contributor.author Cambras, Trinitat
dc.date.available 2017-01-13T21:17:45Z
dc.date.issued 2015-07
dc.identifier.citation Carpentieri, Agata Rita; Oliva, Clara; Diez Noguera, Antoni; Cambras, Trinitat; Melatonin administration modifies circadian motor activity under constant light depending on the lighting conditions during suckling; Taylor & Francis; Chronobiology International; 32; 7; 7-2015; 994-1004
dc.identifier.issn 0742-0528
dc.identifier.uri http://hdl.handle.net/11336/11358
dc.description.abstract Early lighting conditions have been described to produce long-term effects on circadian behavior, which may also influence the response to agents acting on the circadian system. It has been suggested that melatonin (MEL) may act on the circadian pacemaker and as a scavenger of reactive oxygen and nitrogen species. Here, we studied the oxidative and behavioral changes caused by prolonged exposure to constant light (LL) in groups of rats that differed in MEL administration and in lighting conditions during suckling. The rats were exposed to either a light–dark cycle (LD) or LL. At 40 days old, rats were treated for 2 weeks with a daily subcutaneous injection of MEL (10 mg/kg body weight) or a vehicle at activity onset. Blood samples were taken before and after treatment, to determine catalase (CAT) activity and nitrite level in plasma. As expected, LL-reared rats showed a more stable motor activity circadian rhythm than LD rats. MEL treatment produced more reactivity in LD- than in LL rats, and was also able to alter the phase of the rhythm in LD rats. There were no significant differences in nitrite levels or CAT activity between the groups, although both variables increased with time. Finally, we also tested depressive signs by means of sucrose consumption, and anhedonia was found in LD males treated with MEL. The results suggest that the lighting conditions in early infancy are important for the long-term functionality of the circadian system, including rhythm manifestation, responses to MEL and mood alterations.
dc.format application/pdf
dc.language.iso eng
dc.publisher Taylor & Francis
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject MELATONIN
dc.subject CIRCADIAN RHYTHMS
dc.subject SYNCHRONIZATION
dc.subject CONSTANT LIGHT
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Melatonin administration modifies circadian motor activity under constant light depending on the lighting conditions during suckling
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-01-13T19:42:25Z
dc.identifier.eissn 1525-6073
dc.journal.volume 32
dc.journal.number 7
dc.journal.pagination 994-1004
dc.journal.pais Reino Unido
dc.journal.ciudad Milton Park
dc.description.fil Fil: Carpentieri, Agata Rita. Universidad de Barcelona. Facultad de Farmacia; España. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba; Argentina
dc.description.fil Fil: Oliva, Clara. Universidad de Barcelona. Facultad de Farmacia; España
dc.description.fil Fil: Diez Noguera, Antoni. Universidad de Barcelona. Facultad de Farmacia; España
dc.description.fil Fil: Cambras, Trinitat. Universidad de Barcelona. Facultad de Farmacia; España
dc.journal.title Chronobiology International
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://www.tandfonline.com/doi/full/10.3109/07420528.2015.1060243


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    Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD

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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)