Artículo
Salicylic acid enhances Staphylococcus aureus extracellular adhesin protein expression
Alvarez, Lucía Paula
; Barbagelata, María Sol
; Cheung, Ambrose L.; Sordelli, Daniel Oscar
; Buzzola, Fernanda Roxana
Fecha de publicación:
11/2011
Editorial:
Elsevier Science
Revista:
Microbes and Infection
ISSN:
1286-4579
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
One of the virulence factors required by Staphylococcus aureus at the early stages of infection is Eap, a secreted adhesin that binds many host proteins and is upregulated by the two-component regulatory system saeRS. The S. aureus Newman strain harbors a mutation in saeS that is thought to be responsible for the high level of Eap expression in this strain. This study was designed to ascertain whether salicylic acid (SAL) affects the expression of Eap and the internalization of S. aureus into epithelial cells. The strain Newman treated with SAL exhibited increased levels of eap transcription and protein expression. Furthermore, SAL treatment increased the eap promoter activity. SAL treatment enhanced Eap expression in the Newman and in other S. aureus strains that do not carry the mutation in saeS. Internalization of S. aureus eap and sae mutants into the MAC-T epithelial cells was significantly decreased compared with the wild-type counterparts. In conclusion, we demonstrated that a low concentration of SAL increased S. aureus Eap expression possibly due to enhancement of sae. SAL may create the conditions for S. aureus persistence in the host, not only by decreasing the capsular polysaccharide expression as shown before, but also by enhancing Eap expression.
Palabras clave:
EXTRACELLULAR ADHESIN PROTEIN
,
SALICYLIC ACID
,
STAPHYLOCOCCUS AUREUS
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Identificadores
Colecciones
Articulos(IMPAM)
Articulos de INSTITUTO DE INVESTIGACIONES EN MICROBIOLOGIA Y PARASITOLOGIA MEDICA
Articulos de INSTITUTO DE INVESTIGACIONES EN MICROBIOLOGIA Y PARASITOLOGIA MEDICA
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Alvarez, Lucía Paula; Barbagelata, María Sol; Cheung, Ambrose L.; Sordelli, Daniel Oscar; Buzzola, Fernanda Roxana; Salicylic acid enhances Staphylococcus aureus extracellular adhesin protein expression; Elsevier Science; Microbes and Infection; 13; 12-13; 11-2011; 1073-1080
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