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dc.contributor.author
Pissarenko, Andrei
dc.contributor.author
Ruestes, Carlos Javier
dc.contributor.author
Meyers, Marc A.
dc.date.available
2020-09-07T17:53:22Z
dc.date.issued
2020-01
dc.identifier.citation
Pissarenko, Andrei; Ruestes, Carlos Javier; Meyers, Marc A.; Constitutive description of skin dermis: Through analytical continuum and coarse-grained approaches for multi-scale understanding; Elsevier; Acta Biomaterialia; 106; 1; 1-2020; 208-224
dc.identifier.issn
1742-7061
dc.identifier.uri
http://hdl.handle.net/11336/113376
dc.description.abstract
Although there are many successful descriptions of the mechanical response of dermis at different levels of complexity and incorporating varying degrees of the physical phenomena involved in deformation, observations indicate that the unraveling of fibers involves a complex three-dimensional process in which they interact in ways that resemble a braided pattern. Here we develop two complementary treatments to gain a better understanding of the mechanical response of dermis: a) an analytical treatment incorporating fibril stiffness, interfibrillar frictional sliding, and the effect of lateral fibers on the extension of a primary fiber; b) a coarse-grained molecular dynamics model comprised of an array of parallel curved fibrils simulating a fiber. Interfibrillar frictional sliding and stiffness are also captured. Both analytical and molecular dynamics models operate at a scale compatible with the wavelength of collagen fibers (~10 μm). The constitutive description presented here incorporates important physical processes taking place during deformation of dermis and thus represents an advance in our understanding of these phenomena.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
COARSE GRAIN MODELING
dc.subject
COLLAGEN
dc.subject
CONSTITUTIVE MODELING
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MOLECULAR DYNAMICS
dc.subject
SKIN
dc.subject.classification
Otras Ciencias Naturales y Exactas
dc.subject.classification
Otras Ciencias Naturales y Exactas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Constitutive description of skin dermis: Through analytical continuum and coarse-grained approaches for multi-scale understanding
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-06-30T14:17:42Z
dc.journal.volume
106
dc.journal.number
1
dc.journal.pagination
208-224
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Pissarenko, Andrei. University of California at San Diego; Estados Unidos
dc.description.fil
Fil: Ruestes, Carlos Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Interdisciplinario de Ciencias Básicas. - Universidad Nacional de Cuyo. Instituto Interdisciplinario de Ciencias Básicas; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Meyers, Marc A.. University of California at San Diego; Estados Unidos
dc.journal.title
Acta Biomaterialia
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1742706120300404
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.actbio.2020.01.026
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