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Artículo

Switched LPV Glucose Control in Type 1 Diabetes

Colmegna, Patricio HernánIcon ; Sánchez Peña, Ricardo; Gondhalekar, Ravi; Dassau, Eyal; Doyle, Frank J.
Fecha de publicación: 06/2016
Editorial: Institute of Electrical and Electronics Engineers
Revista: Ieee Transactions On Bio-medical Engineering
ISSN: 0018-9294
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Sistemas de Automatización y Control

Resumen

Objective: The purpose of this paper is to regulate the blood glucose level in Type 1 Diabetes Mellitus patients with a practical and flexible procedure that can switch among a finite number of distinct controllers, depending on the user's choice. Methods: A switched linear parameter-varying controller with multiple switching regions, related to hypo-, hyper-, and euglycemia situations, is designed. The key feature is to arrange the controller into a framework that provides stability and performance guaranty. Results: The closed-loop performance is tested on the complete in silico adult cohort of the UVA/Padova metabolic simulator, which has been accepted by the U.S. Food and Drug Administration in lieu of animal trials. The outcome produces comparable or improved results with respect to previous works. Conclusion: The strategy is practical because it is based on a model tuned only with a priori patient information in order to cover the interpatient uncertainty. Results confirm that this control structure yields tangible improvements in minimizing risks of hyper-and hypoglycemia in scenarios with unannounced meals. Significance: This flexible procedure opens the possibility of taking into account, at the design stage, unannounced meals and/or patients' physical exercise.
Palabras clave: ARTIFICIAL PANCREAS , LPV CONTROL , SWITCHING CONTROL , TYPE 1 DIABETES MELLITUS
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/113221
DOI: http://dx.doi.org/10.1109/TBME.2015.2487043
URL: https://ieeexplore.ieee.org/document/7289388
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917468/
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Citación
Colmegna, Patricio Hernán; Sánchez Peña, Ricardo; Gondhalekar, Ravi; Dassau, Eyal; Doyle, Frank J.; Switched LPV Glucose Control in Type 1 Diabetes; Institute of Electrical and Electronics Engineers; Ieee Transactions On Bio-medical Engineering; 63; 6; 6-2016; 1192-1200
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