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dc.contributor.author
Santagapita, Patricio Roman
dc.contributor.author
Gómez Brizuela, Leissy
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Mazzobre, Maria Florencia
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Ramirez, Héctor L.
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Corti, Horacio Roberto
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Villalonga Santana, Reynaldo
dc.contributor.author
Buera, Maria del Pilar
dc.date.available
2020-09-03T20:51:50Z
dc.date.issued
2011-01
dc.identifier.citation
Santagapita, Patricio Roman; Gómez Brizuela, Leissy; Mazzobre, Maria Florencia; Ramirez, Héctor L.; Corti, Horacio Roberto; et al.; β-cyclodextrin modifications as related to enzyme stability in dehydrated systems: Supramolecular transitions and molecular interactions; Elsevier; Carbohydrate Polymers; 83; 1; 1-2011; 203-209
dc.identifier.issn
0144-8617
dc.identifier.uri
http://hdl.handle.net/11336/113194
dc.description.abstract
The effect of β-cyclodextrin modifications (polymerization (PCD) and later carboxymethylation (CMPCD)) on their action as enzyme stabilizers was analyzed during freeze-drying and thermal treatment. Combined polymer-trehalose matrices were also employed. Due to their higher Tg values, PCD and CMPCD provided better structural stability to the freeze-dried formulations than β-CD. However, only PCD was a good excipient to protect invertase both in amorphous and supercooled systems. FT-IR revealed increased protein denaturation in the presence of CMPCD, but not in the presence of PCD. Even though all polymers inhibited/delayed trehalose crystallization, only trehalose (T) combined with PCD (PCD + T) and with β-cyclodextrin (β-CD + T) offered the best stability to the enzyme. In β-CD + T system, trehalose was the main responsible for the protection. In PCD + T system, both additives contributed to improve the enzyme stability. FT-IR and DSC were useful to analyze the combined role of molecular and supramolecular interactions on enzyme stability in dehydrated model systems.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ADDITIVES
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ENZYME STABILITY
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FREEZE-DRIED ENZYME FORMULATIONS
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MODIFIED CYCLODEXTRINS
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POLYCYCLODEXTRIN
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
β-cyclodextrin modifications as related to enzyme stability in dehydrated systems: Supramolecular transitions and molecular interactions
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-09-03T16:58:51Z
dc.journal.volume
83
dc.journal.number
1
dc.journal.pagination
203-209
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Santagapita, Patricio Roman. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Industrias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria; Argentina
dc.description.fil
Fil: Gómez Brizuela, Leissy. Universidad de Matanzas Camilo Cienfuegos; Cuba
dc.description.fil
Fil: Mazzobre, Maria Florencia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Industrias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria; Argentina
dc.description.fil
Fil: Ramirez, Héctor L.. Universidad de Matanzas “Camilo Cienfuegos”; Cuba
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Fil: Corti, Horacio Roberto. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria; Argentina
dc.description.fil
Fil: Villalonga Santana, Reynaldo. Universidad de Matanzas “Camilo Cienfuegos”; Cuba
dc.description.fil
Fil: Buera, Maria del Pilar. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Industrias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria; Argentina
dc.journal.title
Carbohydrate Polymers
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.carbpol.2010.07.041
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0144861710005849
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