In vitro studies of cellular response to DNA damage induced by boron neutron capture therapy

The aim of these studies was to evaluate the mechanisms of cellular response to DNA damage induced by BNCT. Thyroid carcinoma cells were incubated with 10BPA or 10BOPP and irradiated with thermal neutrons. The surviving fraction, the cell cycle distribution and the expression of p53 and Ku70 were analyzed. Different cellular responses were observed for each irradiated group. The decrease of Ku70 in the neutrons +BOPP group could play a role in the increase of sensitization to radiation.

Palabras clave: CELL CYCLE , DAMAGE , DNA , NHEJ

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/113140

URL: https://www.sciencedirect.com/science/article/abs/pii/S0969804311002053

DOI: http://dx.doi.org/10.1016/j.apradiso.2011.03.044

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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY

Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL

Citación

Perona, Marina; Pontiggia, Osvaldo Alejandro; Carpano, Marina; Thomasz, Lisa; Thorp, Silvia Inés; et al.; In vitro studies of cellular response to DNA damage induced by boron neutron capture therapy; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 69; 12; 12-2011; 1732-1736

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