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dc.contributor.author
Cavasotto, Claudio Norberto
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dc.contributor.author
Sánchez Lamas, Maximiliano
dc.contributor.author
Maggini, Julián
dc.date.available
2020-09-01T17:45:13Z
dc.date.issued
2020-08-22
dc.identifier.citation
Cavasotto, Claudio Norberto; Sánchez Lamas, Maximiliano; Maggini, Julián; Functional and druggability analysis of the SARS-CoV-2 proteome; Cold Spring Harbor Laboratory; bioRxiv; 2020; 22-8-2020; 1-59
dc.identifier.issn
2692-8205
dc.identifier.uri
http://hdl.handle.net/11336/112903
dc.description.abstract
The infectious coronavirus disease (COVID-19) pandemic, caused by the coronavirus SARS-CoV-2, appeared in December 2019 in Wuhan, China, and has spread worldwide. As of today, more than 22 million people have been infected, with almost 800,000 fatalities. With the purpose of contributing to the development of effective therapeutics, this work provides an overview of the viral machinery and functional role of each SARS-CoV-2 protein, and a thorough analysis of the structure and druggability assessment of the viral proteome. All structural, non-structural, and accessory proteins of SARS-CoV-2 have been studied, and whenever experimental structural data of SARS-CoV-2 proteins were not available, homology models were built based on solved SARS-CoV structures. Several potential allosteric or protein-protein interaction druggable sites on different viral targets were identified, knowledge that could be used to expand current drug discovery endeavors beyond the cysteine proteases and the polymerase complex. It is our hope that this study will support the efforts of the scientific community both in understanding the molecular determinants of this disease and in widening the repertoire of viral targets in the quest for repurposed or novel drugs against COVID-19.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cold Spring Harbor Laboratory
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
COVID-19
dc.subject
SARS-COV-2
dc.subject
PROTEOME
dc.subject
DRUGGABILITY
dc.subject.classification
Virología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Functional and druggability analysis of the SARS-CoV-2 proteome
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-09-01T13:52:13Z
dc.journal.volume
2020
dc.journal.pagination
1-59
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Cavasotto, Claudio Norberto. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
dc.description.fil
Fil: Sánchez Lamas, Maximiliano. Universidad Austral; Argentina
dc.description.fil
Fil: Maggini, Julián. Universidad Austral; Argentina
dc.journal.title
bioRxiv
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.biorxiv.org/content/10.1101/2020.08.21.261404v1
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1101/2020.08.21.261404
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