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dc.contributor.author
Cordisco, Estefanía
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dc.contributor.author
Sortino, Maximiliano Andrés
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dc.contributor.author
Svetaz, Laura Andrea
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dc.date.available
2020-08-31T21:04:47Z
dc.date.issued
2019-02
dc.identifier.citation
Cordisco, Estefanía; Sortino, Maximiliano Andrés; Svetaz, Laura Andrea; Antifungal activity of traditional medicinal plants from Argentina: effect of their combination with antifungal drugs; Bentham Science Publishers; Current Traditional Medicine; 5; 1; 2-2019; 75-95
dc.identifier.issn
2215-0838
dc.identifier.uri
http://hdl.handle.net/11336/112848
dc.description.abstract
The incidence of fungal infections has experienced a marked increase in the last two decades being limited to a few drugs with serious drawbacks. Combination therapy has emerged as an approach to improve the efficacy of currently used antifungal therapy that also may delay the evolution of resistance. The objectives of this work are to present a bibliographic search on the plants used in traditional medicine in Argentina for ailments related to fungal infections and to investigate the antifungal activity of currently used antifungal drugs in combination with natural extracts. Results of the bibliographic investigation showed that 153 species belonging to 56 families and 120 genera from Argentina are applied to treat signs and symptoms considered to maintain ethnopharmacological uses related to fungal infections, mainly for skin and mucosal conditions. Regarding the evaluation of the antifungal activity of combinations between extracts and antifungal drugs, we observed that extracts from plants species belonging to a genera traditionally used for ailments related to fungal infections have more chances of enhancing the activity of amphotericin B, fluconazole and itraconazole. In addition, we observed that there is a greater chance of finding an enhancement in the activity of the commercial antifungals when the combination is performed with extracts that have shown activity in solitary. Nevertheless, inactive extracts that would have been discarded according to the classic strategy displayed activity in combination and they continue being potential candidates in the search for new antifungals.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science Publishers
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTIFUNGAL
dc.subject
ARGENTINEAN PLANTS
dc.subject
CANDIDA ALBICANS
dc.subject
COMBINATION
dc.subject
ENHANCERS
dc.subject
ETHNOPHARMACOLOGY
dc.subject.classification
Química Orgánica
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Antifungal activity of traditional medicinal plants from Argentina: effect of their combination with antifungal drugs
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-07-01T20:40:12Z
dc.identifier.eissn
2215-0846
dc.journal.volume
5
dc.journal.number
1
dc.journal.pagination
75-95
dc.journal.pais
Emiratos Árabes Unidos
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dc.journal.ciudad
Dubai
dc.description.fil
Fil: Cordisco, Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
dc.description.fil
Fil: Sortino, Maximiliano Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
dc.description.fil
Fil: Svetaz, Laura Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
dc.journal.title
Current Traditional Medicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/2215083804666181002111456
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/165828/article
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