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dc.contributor.author
Sosnik, Alejandro Dario
dc.contributor.author
Carcaboso, Ángel M.
dc.contributor.author
Glisoni, Romina Julieta
dc.contributor.author
Moretton, Marcela Analía
dc.contributor.author
Chiappetta, Diego Andrés
dc.date.available
2020-08-31T20:52:57Z
dc.date.issued
2010-03
dc.identifier.citation
Sosnik, Alejandro Dario; Carcaboso, Ángel M.; Glisoni, Romina Julieta; Moretton, Marcela Analía; Chiappetta, Diego Andrés; New old challenges in tuberculosis: Potentially effective nanotechnologies in drug delivery; Elsevier Science; Advanced Drug Delivery Reviews; 62; 4-5; 3-2010; 547-559
dc.identifier.issn
0169-409X
dc.identifier.uri
http://hdl.handle.net/11336/112836
dc.description.abstract
Tuberculosis (TB) is the second most deadly infectious disease. Despite potentially curative pharmacotherapies being available for over 50 years, the length of the treatment and the pill burden can hamper patient lifestyle. Thus, low compliance and adherence to administration schedules remain the main reasons for therapeutic failure and contribute to the development of multi-drug-resistant (MDR) strains. Pediatric patients constitute a high risk population. Most of the first-line drugs are not commercially available in pediatric form. The design of novel antibiotics attempts to overcome drug resistance, to shorten the treatment course and to reduce drug interactions with antiretroviral therapies. On the other hand, the existing anti-TB drugs are still effective. Overcoming technological drawbacks of these therapeutic agents as well as improving the effectiveness of the drug by targeting the infection reservoirs remains the central aims of Pharmaceutical Technology. In this framework, nanotechnologies appear as one of the most promising approaches for the development of more effective and compliant medicines. The present review thoroughly overviews the state-of-the-art in the development of nano-based drug delivery systems for encapsulation and release of anti-TB drugs and discusses the challenges that are faced in the development of a more effective, compliant and also affordable TB pharmacotherapy.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
COMPLEXATION
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LOCAL DELIVERY TO THE LUNG
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PHARMACEUTICAL NANOTECHNOLOGY
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POLYMERIC AND NON-POLYMERIC NANOPARTICLES
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POLYMERIC MICELLES AND LIPOSOMES
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TARGETING TO ALVEOLAR MACROPHAGES
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TUBERCULOSIS
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Nano-materiales
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Nanotecnología
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
New old challenges in tuberculosis: Potentially effective nanotechnologies in drug delivery
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-08-19T19:39:32Z
dc.journal.volume
62
dc.journal.number
4-5
dc.journal.pagination
547-559
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Sosnik, Alejandro Dario. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Carcaboso, Ángel M.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Glisoni, Romina Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Moretton, Marcela Analía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Chiappetta, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
dc.journal.title
Advanced Drug Delivery Reviews
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0169409X09003640
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.addr.2009.11.023
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