Infectious Bursal Disease Virus non-structural protein VP5 is not a transmembrane protein

Infectious Bursal Disease Virus (IBDV) causes a highly relevant poultry disease that affects young chickens causing, among other effects, immunosuppression. IBDV is a bi-segmented double stranded RNA virus. The smaller ORF of larger RNA segment encodes VP5, a 17-kDa non-structural protein. Although it is an important protein for viral replication cycle, the definition of its specific role and subcellular localization remains unclear. In the present work we demonstrate, using imaging techniques, that VP5 is not a type II transmembrane protein but an intracellular membrane-associated protein. This finding might provide evidences of VP5 interaction with cellular proteins and its functions.

Palabras clave: INFECTIOUS BURSAL DISEASE VIRUS , MEMBRANE TOPOLOGY , PROTEIN LOCALIZATION , VP5

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/112555

URL: http://www.sciencedirect.com/science/article/pii/S0042682215002470

DOI: http://dx.doi.org/10.1016/j.virol.2015.05.003

Colecciones

Articulos(CCT - MAR DEL PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - MAR DEL PLATA

Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)

Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL

Citación

Carballeda, Juan Manuel; Maroniche, Guillermo Andrés; Lucero, María Soledad; Richetta, Matías Daniel; Gómez, Evangelina Raquel; et al.; Infectious Bursal Disease Virus non-structural protein VP5 is not a transmembrane protein; Academic Press Inc Elsevier Science; Virology; 483; 9-2015; 312-317

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