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dc.contributor.author
Correa, Fernando Gabriel
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dc.contributor.author
Ljunggren, Elin
dc.contributor.author
Patil, Jaspal
dc.contributor.author
Wang, Xiaoyang
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Hagberg, Henrik
dc.contributor.author
Mallard, Carina
dc.contributor.author
Sandberg, Mats
dc.date.available
2017-01-12T20:34:32Z
dc.date.issued
2013-04
dc.identifier.citation
Correa, Fernando Gabriel; Ljunggren, Elin; Patil, Jaspal; Wang, Xiaoyang; Hagberg, Henrik; et al.; Time-dependent effects of systemic lipopolysaccharide injection on regulators of antioxidant defense Nrf2 and PGC-1alpha in neonatal rat brain.; Karger; Neuroimmunomodulation.; 20; 4; 4-2013; 185-193
dc.identifier.issn
1021-7401
dc.identifier.uri
http://hdl.handle.net/11336/11245
dc.description.abstract
Background/Aims: Both excitotoxicity and neuroinflammation are associated with oxidative stress. One transcription factor, nuclear factor E2-related factor 2 (Nrf2), and one transcription cofactor, peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α), increase the endogenous antioxidant defence and can thus modulate neuronal cell death. Here, we investigated the temporal effects (after 24 and 72 h) of systemic (i.p.) administration of lipopolysaccharide (LPS) on the cerebral Nrf2 and PGC-1α systems. Methods and Results: Seven-day-old rat pups were injected with LPS (0.3 mg/kg). After 24 h, the protein levels of γ-glutamylcysteine ligase modulatory subunit, γ-glutamylcysteine ligase catalytic subunit, Nrf2, PGC-1α and manganese superoxide dismutase (MnSOD) were increased in parallel with decreased levels of Keap1. These effects were correlated with an increased level of phosphorylated Akt and elevated acetylation of histone 4. In contrast, 72 h following LPS, a decrease in the components of the Nrf2 system in parallel with an increase in Keap1 was observed. The down-regulation after 72 h correlated with phosphorylation of p38 mitogen-activated protein kinase, while there were no changes in PGC-1α and MnSOD protein levels or the acetylation/methylation pattern of histones. Conclusion: Systemic LPS in neonatal rats induced time-dependent changes in brain Nrf2 and PGC-1α that correlated well with the protective effect observed after 24 h (pre-conditioning) and the deleterious effects observed after 72 h (sensitizing) of systemic LPS reported earlier. Collectively, the results point towards Nrf2 and PGC-1α as a possible mechanism behind these effects.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Karger
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Neuroinflammation
dc.subject
Nrf2
dc.subject
Antioxidant System
dc.subject
Pgc-1alpha
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Time-dependent effects of systemic lipopolysaccharide injection on regulators of antioxidant defense Nrf2 and PGC-1alpha in neonatal rat brain.
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-24T17:19:18Z
dc.journal.volume
20
dc.journal.number
4
dc.journal.pagination
185-193
dc.journal.pais
Suiza
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dc.journal.ciudad
Basel
dc.conicet.avisoEditorial
This is the peer-reviewed but unedited manuscript version of the following article: Neuroimmunomodulation 2013;20:185-193 (DOI: 10.1159/000347161)]. The final, published version is available at http://www.karger.com/?doi=10.1159/000347161
dc.description.fil
Fil: Correa, Fernando Gabriel. University of Gothenburg. Institute of Biomedicine; Suecia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil
Fil: Ljunggren, Elin. University of Gothenburg. Institute of Biomedicine; Suecia
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Fil: Patil, Jaspal. University of Gothenburg. Institute of Biomedicine; Suecia
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Fil: Wang, Xiaoyang. University of Gothenburg. Institute of Neuroscience and Physiology; Suecia
dc.description.fil
Fil: Hagberg, Henrik. University of Gothenburg. Institute of Neuroscience and Physiology; Suecia
dc.description.fil
Fil: Mallard, Carina. University of Gothenburg. Institute of Neuroscience and Physiology; Suecia
dc.description.fil
Fil: Sandberg, Mats. University of Gothenburg. Institute of Biomedicine; Suecia
dc.journal.title
Neuroimmunomodulation.
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.karger.com/Article/FullText/347161
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000347161
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096332/
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