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Artículo

Both JNK and apoptosis pathways regulate growth and terminalia rotation during Drosophila genital disc development

Benitez, Sergio GonzaloIcon ; Sosa, Claudia MarcelaIcon ; Tomasini, NicolásIcon ; Macías, Ana
Fecha de publicación: 29/01/2010
Editorial: U B C Press
Revista: International Journal Of Developmental Biology
ISSN: 0214-6282
e-ISSN: 1696-3547
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología del Desarrollo

Resumen

Apoptosis is necessary for the regulation of growth during development, but the precise details of this regulation have not been completely characterized. In this study, we used the Drosophila genital disc as a model to analyze the contribution of apoptosis to growth regulation. We studied the expression or activity of several elements of the apoptotic death pathway such as Drosophila inhibitor of apoptosis1, caspases, the apoptotic genes reaper (rpr) and head involution defective, as well as elements of the Jun-NH2-terminal kinase (JNK) pathway. We found that the JNK pathway is active in a dynamic, asymmetric and genitalia-specific manner. Apoptosis, as measured in terms of the expression of a variety of apoptotic molecules, occurs in a JNK-dependent and -independent manner and was detected among engrailed (en) expressing cells. JNK regulation of apoptotic genes is necessary to control growth in both sexes and rotation in males; this regulatory role is necessary to execute en(+) cell death and to activate expression of rpr in these cells. rpr is up-regulated at antero-posterior borders, and this expression appears to be of particular importance in the control of growth, since the balance between cell proliferation and death in those regions appears to depend on the equilibrium between pro- and anti-apoptotic factors at a cellular level.
Palabras clave: GENITAL DISC , JNK , APOPTOSIS , REAPER , DROSOPHILA
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/112105
URL: http://www.ijdb.ehu.es/web/paper.php?doi=10.1387/ijdb.082724sb
DOI: http://dx.doi.org/10.1387/ijdb.082724sb
URL: https://pubmed.ncbi.nlm.nih.gov/20209437/
Colecciones
Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Citación
Benitez, Sergio Gonzalo; Sosa, Claudia Marcela; Tomasini, Nicolás; Macías, Ana; Both JNK and apoptosis pathways regulate growth and terminalia rotation during Drosophila genital disc development; U B C Press; International Journal Of Developmental Biology; 54; 29-1-2010; 643-653
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