Artículo
Melatonin daily oral supplementation attenuates inflammation and oxidative stress in testes of men with altered spermatogenesis of unknown aetiology
Riviere, Eugenia
; Rossi, Soledad Paola
; Tavalieri, Yamil Ezequiel; Muñoz de Toro, Monica Milagros; Ponzio, Roberto Oscar; Puigdomenech, Elisa; Levalle, Oscar Alberto; Martinez, Gustavos; Terradas, Claudio; Calandra, Ricardo Saul
; Matzkin, Maria Eugenia
; Frungieri, Monica Beatriz
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Fecha de publicación:
09/2020
Editorial:
Elsevier Ireland
Revista:
Molecular and Cellular Endocrinology
ISSN:
0303-7207
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
We have previously shown an inverse correlation between testicular melatonin concentration and inflammation/ oxidative stress-related markers levels in infertile men showing unexplained azoospermia. Here, we evaluated the impact of melatonin oral supplementation (daily 3 mg dose used to treat sleep disorders) in the incidence of local inflammation, oxidative stress, and tubular wall fibrosis development in young and middle-aged infertile adult men. Compared with testes without histological alterations, gonads with morphological abnormalities showed lower melatonin concentration along with increased macrophage numbers, TBARS generation, and expression levels of inflammation-related markers and antioxidant enzymes, as well as tubular wall collagen fibers disorganization and thickening. Melatonin oral supplementation not only increased its own testicular levels but also decreased inflammation- and oxidative stress-related markers levels, and improved the tubular wall aspect. Overall, our work provides insights into the potential benefits of melatonin on the inflammatory and oxidative status in testes of patients suffering from unexplained infertility
Palabras clave:
MALE INFERTILITY
,
TESTIS
,
INFLAMMATION
,
OXIDATIVE STRESS
,
MELATONIN
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Riviere, Eugenia; Rossi, Soledad Paola; Tavalieri, Yamil Ezequiel; Muñoz de Toro, Monica Milagros; Ponzio, Roberto Oscar; et al.; Melatonin daily oral supplementation attenuates inflammation and oxidative stress in testes of men with altered spermatogenesis of unknown aetiology; Elsevier Ireland; Molecular and Cellular Endocrinology; 515; 110889; 9-2020; 1-14
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