Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis

Azole drugs such as econazole, are active on Mycobacterium tuberculosis and Mycobacterium smegmatis; however, the identification of their target(s) is still pending. It has been reported that mutations in the non-essential system mmpL5-mmpS5 conferred resistance to econazole in M. tuberculosis. We herein report that an azole-resistant mutant screen in M. smegmatis rendered mutations in rshA, encoding a non-essential anti-sigma H protein.

Palabras clave: Mycobacterium smegmatis , Mycobacterium tuberculosis , econazole , RshA , Mycobacterium smegmatis

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)

Identificadores

URI: http://hdl.handle.net/11336/111754

URL: https://www.microbiologyresearch.org/content/journal/acmi/10.1099/acmi.0.000070

DOI: https://doi.org/10.1099/acmi.0.000070

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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)

Citación

Morbidoni, Héctor Ricardo; de la Iglesia, Agustina Inés; Figueroa, Virginia; Di Capua, Cecilia Beatriz; Ioerger, Thomas R.; et al.; Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis; Microbiological Society Korea; Access Microbiology; 1; 10; 12-2019; 1-7

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