Artículo
Salivary testosterone: a reliable approach to the diagnosis of male hypogonadism
Arregger, Alejandro Luis
; Contreras, Liliana Noemí
; Tumilasci, Omar Rene
; Aquilano, Daniel R; Cardoso, Estela M. del Luján
Fecha de publicación:
11/2007
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
Clinical Endocrinology
ISSN:
0300-0664
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Summary Objetive The purpose of this study was to demonstrate that Sal-T is a reliable biomarker of androgen status in the diagnosis of male hypogonadism. Design In order to validate the salivary testosterone assay (Sal-T), its reproducibility , the agreement with serum free testosterone levels (Free-T) , the correlation with other circulating androgen markers ( bioavailable testosterone , total testosterone) and cut off values were defined. Patients and Methods We studied 52 eugonadic (E) and 20 hypogonadic (Hy) men. Sal-T was assayed using an adapted radioimmunoassay for serum testosterone. Sal-T concentrations were compared in 9 cases before and after citric acid stimulation of salivary flow-rate. Free-T and bioavailable testosterone (Bio-T) were calculated by Vermeulen equation and SHBG were determined by binding assay. Results Sal-T did not depend on salivary flow-rate and morning samples from 7.00 to 9.00 h were stable. Agreement between Sal-T and Free-T measurements was confirmed in all subjects . Sal-T levels correlated positively with all circulating androgens , showing the best correlation with Free-T in E (r=0.92) as well as in Hy (r=0.97).A cutoff value for Sal-T £ 0.195 nM showed 100% of sensibility and specificity to rule out hypogonadism. Conclusions Our data showed that Sal-T is a reliable marker of testosterone bioavailability. The results support the inclusion of this biomarker as a non invasive approach in the diagnosis of male androgen deficiency.
Palabras clave:
salivary testosterone
,
diagnosis
,
male hypogonadism
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IDIM)
Articulos de INST.DE INVEST.MEDICAS
Articulos de INST.DE INVEST.MEDICAS
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Arregger, Alejandro Luis; Contreras, Liliana Noemí; Tumilasci, Omar Rene; Aquilano, Daniel R; Cardoso, Estela M. del Luján; Salivary testosterone: a reliable approach to the diagnosis of male hypogonadism; Wiley Blackwell Publishing, Inc; Clinical Endocrinology; 67; 5; 11-2007; 656-662
Compartir
Altmétricas