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Artículo

Moxidectin and ivermectin metabolic stability in sheep ruminal and abomasal contents

Lifschitz, Adrian LuisIcon ; Virkel, Guillermo LeonIcon ; Ballent, MarianaIcon ; Sallovitz, Juan Manuel; Pis, A.; Lanusse, Carlos EdmundoIcon
Fecha de publicación: 10/2005
Editorial: Wiley Blackwell Publishing, Inc
Revista: Journal of Veterinary Pharmacology and Therapeutics
ISSN: 0140-7783
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Ciencias Veterinarias

Resumen

The oral administration of macrocyclic lactones to sheep leads to poorer efficacy and shorter persistence of the antiparasitic activity compared to the subcutaneous treatment. Gastrointestinal biotransformation occurring after oral treatment to ruminant species has been considered as a possible cause of the differences observed between routes of administration. The current work was addressed to evaluate on a comparative basis the in vitro metabolism of moxidectin (MXD) and ivermectin (IVM) in sheep ruminal and abomasal contents. Both compounds were incubated under anaerobic conditions during 2, 6 and 24 h in ruminal and abomasal contents collected from untreated adult sheep. Drug concentrations were measured by high-performance liquid chromatography with fluorescence detection after sample clean up and solid phase extraction. Neither MXD nor IVM suffered metabolic conversion and/or chemical degradation after 24-h incubation in ruminal and abomasal contents collected from adult sheep. Unchanged MXD and IVM parent compounds represented between 95.5 and 100% of the total drug recovered in the ruminal and abomasal incubation mixtures compared with those measured in inactive control incubations. The partition of both molecules between the solid and fluid phases of both sheep digestive contents was assessed. MXD and IVM were extensively bound (>90%) to the solid material of both ruminal and abomasal contents collected from sheep fed on lucerne hay. The results reported here confirm the extensive degree of association to the solid digestive material and demonstrates a high chemical stability without evident metabolism and/or degradation for both MXD and IVM in ruminal and abomasal contents.
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/111645
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2885.2005.00674.x
DOI: http://dx.doi.org/10.1111/j.1365-2885.2005.00674.x
Colecciones
Articulos(CCT - TANDIL)
Articulos de CTRO CIENTIFICO TECNOLOGICO CONICET - TANDIL
Articulos(CIVETAN)
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Citación
Lifschitz, Adrian Luis; Virkel, Guillermo Leon; Ballent, Mariana; Sallovitz, Juan Manuel; Pis, A.; et al.; Moxidectin and ivermectin metabolic stability in sheep ruminal and abomasal contents; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 28; 5; 10-2005; 411-418
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