Artículo
Modulation of the Notch system in response to Wnt inhibition induces restoration of the rat luteal function
Accialini, Paula Lucia
; Bechis, Andrés; Irusta, Griselda
; Bianchi, Silvia María; Parborell, Maria Fernanda Agustina
; Abramovich, Dahia; Tesone, Marta
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
01/2020
Editorial:
SAGE Publications
Revista:
Reproductive Sciences
ISSN:
1933-7191
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The aim of this study was to investigate whether the Notch pathway is modulated in response to the downregulation of the Wnt/ Β-catenin system in corpora lutea (CLs) from superovulated rats. To this end, we analyzed the effect of in vitro CLWnt/Β-catenin inhibition on the expression of Notch members and on luteal function. Mechanically isolated rat CLs were cultured with ICG001, a Wnt/B-catenin inhibitor. In this system, Wnt/B-catenin inhibition reduced progesterone production and decreased StAR protein levels. Besides, Wnt/B-catenin inhibition stimulated the Notch system, evidenced by an increase in Hes1 expression, and promoted the expression of selected Notch family members. At long incubation times, StAR levels and progesterone concentration reached the control values, effects probably mediated by the Notch pathway. These results provide the first evidence of a compensatory mechanism between Wnt/B-catenin signaling and the Notch system, which contributes to the homeostasis of luteal cells.
Palabras clave:
WNT/B-CATENIN
,
NOTCH
,
CORPUS LUTEUM
,
STAR
,
HES1
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Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Accialini, Paula Lucia; Bechis, Andrés; Irusta, Griselda; Bianchi, Silvia María; Parborell, Maria Fernanda Agustina; et al.; Modulation of the Notch system in response to Wnt inhibition induces restoration of the rat luteal function; SAGE Publications; Reproductive Sciences; 27; 2; 1-2020; 503-512
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