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dc.contributor.author
Bravo Roca, María Fernanda
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Mauro, Laura Valeria
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Morandi, Ana
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Bonadeo, Fernando
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Vaccaro, Carlos Alberto
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Quintana, Guillermo Ojea
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Specterman, Sergio
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Bal, Elisa Dora
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Pallotta, María Guadalupe
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Puricelli, Lydia Ines
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Lastiri, José
dc.date.available
2020-08-11T18:38:50Z
dc.date.issued
2006-12
dc.identifier.citation
Bravo Roca, María Fernanda; Mauro, Laura Valeria; Morandi, Ana; Bonadeo, Fernando; Vaccaro, Carlos Alberto; et al.; Prognostic value of E-cadherin, beta-catenin, MMPs (7 and 9), and TIMPs (1 and 2) in patients with colorectal carcinoma; Veterinary and Human Toxicology; Journal of Surgical Oncology; 93; 12-2006; 151-160
dc.identifier.issn
0022-4790
dc.identifier.uri
http://hdl.handle.net/11336/111455
dc.description.abstract
BACKGROUND AND OBJECTIVES: Therapy of colorectal tumors (CRC) based on histology and clinical factors is insufficient to predict the evolution of each patient. The finding of molecular abnormalities able to differentiate subgroups of patients with bad prognosis will improve our ability to treat them successfully. Our purpose was to analyze retrospectively the prognostic input of E-cadherin, beta-catenin, metalloproteinases (MMPs) (7 and 9), and tissue inhibitors of metalloproteinases (TIMPs) (1 and 2) in patients with a follow-up period of 5 years. METHODS: Antigen expression was analyzed by immunohistochemistry. Prognostic evaluation was performed with the multivariate proportional hazards model. RESULTS: We demonstrated a concomitant loss of E-cadherin and beta-catenin at membranous level and an abnormal accumulation of nuclear beta-catenin. Besides, we found that all MMPs and TIMPs studied were overexpressed in CRC tissue. There was no association between the expression of any of these molecules and the known clinical-pathological parameters employed in CRC pathology. A multivariate analysis demonstrated that the overall survival could be independently predicted by the loss of E-cadherin and the overexpression of TIMP-2. CONCLUSIONS: The expression of E-cadherin and TIMP-2 could be relevant in determining the prognosis of CRC patients and providing a more accurate mechanism for their classification. (c) 2006 Wiley-Liss, Inc.
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application/pdf
dc.language.iso
eng
dc.publisher
Veterinary and Human Toxicology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
colorectal tumors
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metalloproteinases
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Prognostic
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E-cadherin
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Otros tipos de Medicina Clínica
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Prognostic value of E-cadherin, beta-catenin, MMPs (7 and 9), and TIMPs (1 and 2) in patients with colorectal carcinoma
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-07-21T20:20:39Z
dc.journal.volume
93
dc.journal.pagination
151-160
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Bravo Roca, María Fernanda. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
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Fil: Mauro, Laura Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
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Fil: Morandi, Ana. Hospital Italiano; Argentina
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Fil: Bonadeo, Fernando. Hospital Italiano; Argentina
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Fil: Vaccaro, Carlos Alberto. Hospital Italiano; Argentina
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Fil: Quintana, Guillermo Ojea. Hospital Italiano; Argentina
dc.description.fil
Fil: Specterman, Sergio. Hospital Italiano; Argentina
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Fil: Bal, Elisa Dora. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Ministerio de Ciencia. Tecnología e Innovación Productiva. Agencia Nacional de Promoción Científica y Tecnológica; Argentina
dc.description.fil
Fil: Pallotta, María Guadalupe. Hospital Italiano; Argentina
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Fil: Puricelli, Lydia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina
dc.description.fil
Fil: Lastiri, José. Hospital Italiano; Argentina
dc.journal.title
Journal of Surgical Oncology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/16425303/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/jso.20413
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