Artículo
Signaling pathways leading to prostaglandin E2 production by rat cerebral frontal cortex
Fecha de publicación:
04/2006
Editorial:
Elsevier
Revista:
Prostaglandins Leukotrienes and Essential Fatty Acids
ISSN:
0952-3278
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In this paper, we have determined the effect of both muscarinic acetylcholine receptor (mAChR) and exogenous prostaglandin E(2) (PGE(2)) on PGE(2) production and cyclooxygenases (COX) mRNA gene expression on rat cerebral frontal cortex. Carbachol and PGE(2) increase endogenous PGE(2) production and the COX-1 mRNA levels by activation of PLA(2)s. The COX-1 and COX-2 activity participated in the production of PGE(2) triggered by exogenous PGE(2). While in carbachol-PGE(2) only COX-1 activity is affected. The specific inhibition of PGE(2) receptor was able to impair the increase of endogenous PGE(2) production triggered by both carbachol and exogenous PGE(2). These results suggest that carbachol-activation mAChR increased PGE(2) production that in turn interacting with its own receptor triggers an additional production of PGE(2). Both mechanisms appear to occur by using PLA(2) signaling system. This data should be able to contribute to understand the involvement of PGE(2) in normal brain function and its participation in neuroinflammatory processes.
Palabras clave:
prostaglandin E(2) production
,
rat cerebral frontal cortex
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Orman, Betina; Reina, Silvia Lorena; Sterin Borda, Leonor Josefina; Borda, Enri Santiago; Signaling pathways leading to prostaglandin E2 production by rat cerebral frontal cortex; Elsevier; Prostaglandins Leukotrienes and Essential Fatty Acids; 74; 4; 4-2006; 255-262
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