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dc.contributor.author
Alvarez, Hector Manuel  
dc.contributor.author
Steinbüchel, Alexander  
dc.contributor.other
Alvarez, Hector Manuel  
dc.date.available
2020-08-07T16:46:05Z  
dc.date.issued
2019  
dc.identifier.citation
Alvarez, Hector Manuel; Steinbüchel, Alexander; Biology of triacylglycerol accumulation by Rhodococcus; Springer; 16; 2019; 299-332  
dc.identifier.isbn
978-3-030-11461-9  
dc.identifier.uri
http://hdl.handle.net/11336/111179  
dc.description.abstract
Members of the genus Rhodococcus are specialist in the accumulation of triacylglycerols (TAG). Some of them can be considered oleaginous microorganisms since they are able to produce significant amounts of those lipids under certain conditions. In this context, R. opacus strain PD630 and R. jostii RHA1 became models among prokaryotes in this research area. The basic knowledge generated for rhodococci could be also extrapolated to related microorganisms with clinical importance, such as mycobacteria. The biosynthesis and accumulation of TAG by species of the genus Rhodococcus and other actinomycetes seems to be a process linked to the stationary growth phase or as a response to stress. The chemical structure of rhodococcal TAG can be controlled by the composition of the carbon source used. The biosynthesis and accumulation of novel TAG containing unusual components, such as aromatic and isoprenoid fatty acids, by members of Rhodococcus and related genera has been reported. The low specificity of wax ester synthase/diacylglycerol acyltransferase enzymes (WS/DGAT), which catalyze TAG biosynthesis in prokaryotes, may contribute to the high variability of TAG composition. The occurrence of genes coding for WS/DGAT enzymes is highly redundant in rhodococcal genomes. The enrichment of genes and enzymes involved in TAG metabolism in rhodococci suggest an important role of these lipids in the physiology of these microorganisms. Genomic, transcriptomic and proteomic data from TAG-accumulating rhodococci are now available and some genes coding for enzymes of the central metabolism, the Kennedy pathway, lipid transporter proteins, structural lipid inclusion bodies associated proteins, and transcriptional regulatory proteins have been identified and characterized. This article aims to summarize the most relevant achievements of basic research in this field, including the most recent knowledge emerged from studies on TAG accumulation by rhodococci.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
RHODOCOCCUS  
dc.subject
TRIACYLGLYCEROLS  
dc.subject.classification
Bioquímica y Biología Molecular  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Biology of triacylglycerol accumulation by Rhodococcus  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.type
info:eu-repo/semantics/bookPart  
dc.type
info:ar-repo/semantics/parte de libro  
dc.date.updated
2020-06-08T16:02:43Z  
dc.journal.volume
16  
dc.journal.pagination
299-332  
dc.journal.pais
Suiza  
dc.description.fil
Fil: Alvarez, Hector Manuel. Universidad Nacional de la Patagonia "San Juan Bosco". Instituto de Biociencias de la Patagonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Biociencias de la Patagonia; Argentina  
dc.description.fil
Fil: Steinbüchel, Alexander. Westfälische Wilhelms Universität; Alemania. King Abdulaziz University; Arabia Saudita  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.springer.com/gp/book/9783030114602  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.1007/978-3-030-11461-9_11  
dc.conicet.paginas
386  
dc.source.titulo
Biology of Rhodococcus