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dc.contributor.author
Angel, Sergio Oscar
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dc.contributor.author
Matrajt, Mariana
dc.contributor.author
Echeverria, Pablo
dc.date.available
2017-01-11T15:12:21Z
dc.date.issued
2013-03
dc.identifier.citation
Angel, Sergio Oscar; Matrajt, Mariana; Echeverria, Pablo; A review of recent patents on the protozoan parasite HSP90 as a drug target; Bentham Science; Recent Patent on Biotechnology; 7; 3-2013; 2-8
dc.identifier.issn
1872-2083
dc.identifier.uri
http://hdl.handle.net/11336/11111
dc.description.abstract
Diseases caused by protozoan parasites are still an important health problem. These parasites can cause a wide spectrum of diseases, some of which are severe and have high morbidity or mortality if untreated. Since they are still uncontrolled, it is important to find novel drug targets and develop new therapies to decrease their remarkable social and economic impact on human societies. In the past years, human HSP90 has become an interesting drug target that has led to a large number of investigations both at state organizations and pharmaceutical companies, followed by clinical trials. The finding that HSP90 has important biological roles in some protozoan parasites like Plasmodium spp, Toxoplasma gondii and trypanosomatids has allowed the expansion of the results obtained in human cancer to these infections. This review summarizes the latest important findings showing protozoan HSP90 as a drug target and presents three patents targeting T. gondii, P. falciparum and trypanosomatids HSP90.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Toxoplasma Gondii
dc.subject
Choque Termico
dc.subject
Hsp90
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Terapia
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
A review of recent patents on the protozoan parasite HSP90 as a drug target
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-17T16:03:23Z
dc.journal.volume
7
dc.journal.pagination
2-8
dc.journal.pais
Arabia Saudita
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dc.journal.ciudad
Sharjah
dc.description.fil
Fil: Angel, Sergio Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Biotecnológicas - Instituto Tecnológico Chascomús. Instituto de Investigaciones Biotecnológicas (sede Chascomús); Argentina
dc.description.fil
Fil: Matrajt, Mariana. University of Vermont; Estados Unidos
dc.description.fil
Fil: Echeverria, Pablo. Université de Genève Sciences III; Suiza
dc.journal.title
Recent Patent on Biotechnology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706948/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/108369/article
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/1872208311307010002
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