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dc.contributor.author
Ortega, Hugo Hector
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dc.contributor.author
Veiga-Lopez, A.
dc.contributor.author
Sreedharan, S.
dc.contributor.author
Velázquez, Melisa María del Luján
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dc.contributor.author
Salvetti, Natalia Raquel
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dc.contributor.author
Padmanabhan, Vasantha
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dc.date.available
2020-08-06T14:13:14Z
dc.date.issued
2015-10
dc.identifier.citation
Ortega, Hugo Hector; Veiga-Lopez, A.; Sreedharan, S.; Velázquez, Melisa María del Luján; Salvetti, Natalia Raquel; et al.; Developmental Programming: Does Prenatal Steroid Excess Disrupt the Ovarian VEGF System in Sheep?1; Society for the Study of Reproduction; Biology of Reproduction; 93; 3; 10-2015; 58-65
dc.identifier.issn
0006-3363
dc.identifier.uri
http://hdl.handle.net/11336/110986
dc.description.abstract
Prenatal testosterone (T), but not dihydrotestosterone (DHT), excess disrupts ovarian cyclicity and increases follicular recruitment and persistence. We hypothesized that the disruption in the vascular endothelial growth factor (VEGF) system contributes to the enhancement of follicular recruitment and persistence in prenatal T-treated sheep. Impact of T / DHT treatments from days 30-90 of gestation on VEGFA, VEGFB, and their receptor (VEGFR-1 (FLT1), VEGFR-2 (KDR), and VEGFR-3 (FLT4)) protein expression was examined by immunohistochemistry on fetal day 90, 140, 22 weeks, 10 months (postpubertal), and 21 months (adult) of age. Arterial morphometry was performed in fetal day 140 and postpubertal ovaries. VEGFA and VEGFB expression were found in granulosa cells at all stages of follicular development with increased expression in antral follicles. VEGFA was present in theca interna, while VEGFB was present in theca interna / externa, and stromal cells. All 3 receptors were expressed in the granulosa, theca, and stromal cells during all stages of follicular development. VEGFR-3 increased with follicular differentiation with the highest level seen in the granulosa cells of antral follicles. None of the members of the VEGF family or their receptor expression were altered by age, or prenatal T / DHT treatments. At fetal day 140, area, wall thickness, and wall area of arteries from the ovarian hilum were larger in prenatal T- and DHT-treated females, suggestive of early androgenic programming of arterial differentiation. This may facilitate increased delivery of endocrine factors and thus indirectly contribute to the development of multifollicular phenotype.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society for the Study of Reproduction
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ADIPOSE TISSUE
dc.subject
GROWTH
dc.subject
INSULIN
dc.subject
LEPTIN
dc.subject
OVARY
dc.subject
STEROIDOGENESIS
dc.subject.classification
Otras Ciencias Médicas
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dc.subject.classification
Otras Ciencias Médicas
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Developmental Programming: Does Prenatal Steroid Excess Disrupt the Ovarian VEGF System in Sheep?1
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-08-05T16:38:59Z
dc.journal.volume
93
dc.journal.number
3
dc.journal.pagination
58-65
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Madison
dc.description.fil
Fil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
dc.description.fil
Fil: Veiga-Lopez, A.. University of Michigan; Estados Unidos
dc.description.fil
Fil: Sreedharan, S.. University of Michigan; Estados Unidos
dc.description.fil
Fil: Velázquez, Melisa María del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
dc.description.fil
Fil: Salvetti, Natalia Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
dc.description.fil
Fil: Padmanabhan, Vasantha. University of Michigan; Estados Unidos
dc.journal.title
Biology of Reproduction
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1095/biolreprod.115.131607
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