Artículo
7-oxo-DHEA enhances impaired M. tuberculosis-specific T cell responses during HIV-TB coinfection
Vecchione, María Belén
; Laufer, Natalia Lorna
; Sued, Omar Gustavo; Corti, Marcelo; Salomon, Horacio Eduardo
; Quiroga, María Florencia
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Fecha de publicación:
01/2020
Editorial:
BioMed Central
Revista:
Journal Of Biomedical Science
ISSN:
1423-0127
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), affecting approximately one third of the world’s population. Development of an adequate immune response will determine disease progression or progress to chronic infection. Risk of developing TB among human immunodeficiency virus (HIV)-coinfected patients (HIV-TB) is 20–30 times higher than those without HIV infection, and a synergistic interplay between these two pathogens accelerates the decline in immunological functions. TB treatment in HIV-TB coinfected persons is challenging and it has a prolonged duration, mainly due to the immune system failure to provide an adequate support for the therapy. Therefore, we aimed to study the role of the hormone 7-oxo-dehydroepiandrosterone (7-OD) as a modulator of anti-tuberculosis immune responses in the context of HIV-TB coinfection.
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Articulos(INBIRS)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA
Citación
Vecchione, María Belén; Laufer, Natalia Lorna; Sued, Omar Gustavo; Corti, Marcelo; Salomon, Horacio Eduardo; et al.; 7-oxo-DHEA enhances impaired M. tuberculosis-specific T cell responses during HIV-TB coinfection; BioMed Central; Journal Of Biomedical Science; 27; 1; 1-2020; 1-23
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