Artículo

Insertion (4;11)(q27;q24q21) in a patient with essential thrombocythemia with progression to myelofibrosis

Gargallo, Patricia Martha; Hagemeijer, Anne; Vassallu, Patricia; Kornblihtt, Laura Inés; Heller, Paula GracielaIcon ; Molinas, Felisa ConcepciónIcon ; Larripa, Irene BeatrizIcon
Fecha de publicación: 10/2004
Editorial: Elsevier Science Inc
Revista: Cancer Genetics And Cytogenetics
ISSN: 0165-4608
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

We report a case of essential thrombocythemia (ET) in a 39-year-old woman who developed myelofibrosis at follow-up. The cytogenetic and fluorescence in situ hybridization analyses revealed a pathologic clone with the following previously unreported karyotype: 46,XX,ins(4;11)(q27;q24q21). We cannot conclude that the presence of this inverted insertion was associated with the overproduction of platelets, but documentation of more cases with chromosomal abnormalities and ET should lead to identifying different candidate genes involved in the neoplastic growth.
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/110545
URL: https://www.cancergeneticsjournal.org/article/S0165-4608(04)00062-7/fulltext
DOI: https://doi.org/10.1016/j.cancergencyto.2004.01.025
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Citación
Gargallo, Patricia Martha; Hagemeijer, Anne; Vassallu, Patricia; Kornblihtt, Laura Inés; Heller, Paula Graciela; et al.; Insertion (4;11)(q27;q24q21) in a patient with essential thrombocythemia with progression to myelofibrosis; Elsevier Science Inc; Cancer Genetics And Cytogenetics; 154; 1; 10-2004; 72-76
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