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dc.contributor.author
Mazzeo, Marcelo Adrián
dc.contributor.author
Linares, Jorge Alberto
dc.contributor.author
López, María Marcela
dc.contributor.author
Bachmeier, Evelin
dc.contributor.author
Wietz, Fernando Martín
dc.contributor.author
Galván Josa, Víctor Martín
dc.contributor.author
Valentinuzzi, Maria Cecilia
dc.contributor.author
Riveros de la Vega, Jose Alberto
dc.contributor.author
Finkelberg, Ana Beatriz
dc.date.available
2017-01-10T18:40:11Z
dc.date.issued
2013-11
dc.identifier.citation
Mazzeo, Marcelo Adrián; Linares, Jorge Alberto; López, María Marcela; Bachmeier, Evelin; Wietz, Fernando Martín; et al.; Analysis of Saliva Samples from Oncological Patients Treated with 5-Fluorouracil and Leucovorin Calcium by Scanning Electron Microscopy with Energy Dispersive System; Wiley; Journal Of Oral Pathology And Medicine; 42; 10; 11-2013; 788-792
dc.identifier.issn
0904-2512
dc.identifier.uri
http://hdl.handle.net/11336/11041
dc.description.abstract
This work presents a chemical and morphological analysis of samples of saliva taken from patients who were under treatment with intravenous chemotherapy with 5-fluorouracil and leucovorin calcium. Samples of saliva were extracted from fifteen patients during the three stages of the treatment: The initial stage (previous to the chemotherapy), the intermediate stage (during the chemotherapy), and the final stage (twenty-one days after finishing the treatment). An amount of 50 ll was collected in each visit. Chemical contrast images were taken by means of scanning electron microscopy, and X-ray characteristic spectra were obtained from all the studied samples by using an energy dispersive system from all the studied samples. Images that correspond to the intermediate stage showed important differences with respect to the initial and final stages. In addition, X-ray spectra provided information about the present elements in saliva and their relative abundance allowed us to determine variations in the chemical composition. The backscattered electron images and X-ray spectra from the intermediate stage showed clusters of crystals with fluorine content higher than those obtained in initial and final stages. This fact probably indicates the passage of metabolites of 5-fluorouracil and leucovorin calcium from the plasma to the oral cavity. This finding enhances the hypothesis proposed by other authors about the secondary effects of the drugs on the stomatognathic system such as oral mucositis, dysgeusia, and xerostomia with or without hyposalivation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
5 Fluorouracil
dc.subject
Saliva
dc.subject
Sem-Eds
dc.subject.classification
Odontología, Medicina y Cirugía Oral
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Analysis of Saliva Samples from Oncological Patients Treated with 5-Fluorouracil and Leucovorin Calcium by Scanning Electron Microscopy with Energy Dispersive System
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-01-06T20:03:51Z
dc.identifier.eissn
1600-0714
dc.journal.volume
42
dc.journal.number
10
dc.journal.pagination
788-792
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Mazzeo, Marcelo Adrián. Universidad Nacional de Cordoba. Facultad de Odontologia. Catedra de Fisiologia; Argentina
dc.description.fil
Fil: Linares, Jorge Alberto. Universidad Nacional de Cordoba. Facultad de Odontologia. Catedra de Fisiologia; Argentina
dc.description.fil
Fil: López, María Marcela. Universidad Nacional de Cordoba. Facultad de Odontologia. Catedra de Fisiologia; Argentina
dc.description.fil
Fil: Bachmeier, Evelin. Universidad Nacional de Cordoba. Facultad de Odontologia. Catedra de Fisiologia; Argentina
dc.description.fil
Fil: Wietz, Fernando Martín. Universidad Nacional de Cordoba. Facultad de Odontologia. Catedra de Fisiologia; Argentina
dc.description.fil
Fil: Galván Josa, Víctor Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
dc.description.fil
Fil: Valentinuzzi, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
dc.description.fil
Fil: Riveros de la Vega, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
dc.description.fil
Fil: Finkelberg, Ana Beatriz. Universidad Nacional de Cordoba. Facultad de Odontologia. Catedra de Fisiologia; Argentina
dc.journal.title
Journal Of Oral Pathology And Medicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/jop.12078/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/jop.12078


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