Artículo
α-MSH and γ-MSH modulate early release of hypothalamic PGE2 and NO induced by IL-1β differently
Cragnolini, Andrea Beatriz
; Caruso, Carla Mariana
; Lasaga, Mercedes Isabel
; Scimonelli, Teresa Nieves
Fecha de publicación:
12/2006
Editorial:
Elsevier Ireland
Revista:
Neuroscience Letters
ISSN:
0304-3940
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Interleukin-1beta (IL-1beta) stimulates corticotropin-releasing hormone (CRH) secretion in hypothalamus, which involves the release of prostaglandins (PGE2) and nitric oxide (NO). We have demonstrated that melanocortins can inhibit the early effects of IL-1beta on the HPA axis by acting on the central nervous system (CNS). Our study investigated whether alpha-melanocyte stimulating hormone (alpha-MSH) and gamma-MSH could inhibit IL-1beta-induced PGE2 and NO release in hypothalamus in the rapid activation of the HPA axis. An i.c.v. injection of 12.5 ng/microl of IL-1beta significantly increased the release of PGE2 and NOS activity in the hypothalamus. Treatment with alpha-MSH (0.1 microg/microl) inhibited the effect of IL-1beta on PGE2 release. Also, gamma-MSH (1 microg/microl) eliminated the increase in NOS activity induced by IL-1beta. Our data indicate the modulatory role of melanocortins in the early hypothalamic response to IL-1beta, with different regulation of PGE2 and NO release.
Palabras clave:
PROSTAGLANDIN
,
NITRIC OXIDE
,
INTERLEUKIN-1BETA
,
MELANOCORTINS
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IFEC)
Articulos de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Articulos de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Articulos(INBIOMED)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Cragnolini, Andrea Beatriz; Caruso, Carla Mariana; Lasaga, Mercedes Isabel; Scimonelli, Teresa Nieves; α-MSH and γ-MSH modulate early release of hypothalamic PGE2 and NO induced by IL-1β differently; Elsevier Ireland; Neuroscience Letters; 409; 3; 12-2006; 168-172
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