Repositorio Institucional
Repositorio Institucional
CONICET Digital
  • Inicio
  • EXPLORAR
    • AUTORES
    • DISCIPLINAS
    • COMUNIDADES
  • Estadísticas
  • Novedades
    • Noticias
    • Boletines
  • Ayuda
    • General
    • Datos de investigación
  • Acerca de
    • CONICET Digital
    • Equipo
    • Red Federal
  • Contacto
JavaScript is disabled for your browser. Some features of this site may not work without it.
  • INFORMACIÓN GENERAL
  • RESUMEN
  • ESTADISTICAS
 
Artículo

Regulation of FKBP51 and FKBP52 functions by post-translational modifications

Daneri Becerra, Cristina del RosarioIcon ; Zgajnar, Nadia RominaIcon ; Lotufo, Cecilia MaricelIcon ; Ramos Hryb, Ana BelenIcon ; Piwien Pilipuk, GracielaIcon ; Galigniana, Mario DanielIcon
Fecha de publicación: 10/2019
Editorial: Portland Press
Revista: Biochemical Society Transactions
ISSN: 0300-5127
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

FKBP51 and FKBP52 are two iconic members of the family of peptidyl-prolyl-(cis/trans)-isomerases (EC: 5.2.1.8), which comprises proteins that catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds in unfolded and partially folded polypeptide chains and native state proteins. Originally, both proteins have been studied as molecular chaperones belonging to the steroid receptor heterocomplex, where they were first discovered. In addition to their expected role in receptor folding and chaperoning, FKBP51 and FKBP52 are also involved in many biological processes, such as signal transduction, transcriptional regulation, protein transport, cancer development, and cell differentiation, just to mention a few examples. Recent studies have revealed that both proteins are subject of post-translational modifications such as phosphorylation, SUMOlyation, and acetylation. In this work, we summarize recent advances in the study of these immunophilins portraying them as scaffolding proteins capable to organize protein heterocomplexes, describing some of their antagonistic properties in the physiology of the cell, and the putative regulation of their properties by those post-translational modifications.
Palabras clave: IMMUNOPHILINS , FKBP51 , FKBP52 , POST-TRANSLATIONAL MODIFICATIONS
Ver el registro completo
 
Archivos asociados
Tamaño: 6.058Mb
Formato: PDF
.
Solicitar
Licencia
info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/110261
URL: https://portlandpress.com/biochemsoctrans/article/doi/10.1042/BST20190334/221203
DOI: http://dx.doi.org/10.1042/BST20190334
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Daneri Becerra, Cristina del Rosario; Zgajnar, Nadia Romina; Lotufo, Cecilia Maricel; Ramos Hryb, Ana Belen; Piwien Pilipuk, Graciela; et al.; Regulation of FKBP51 and FKBP52 functions by post-translational modifications; Portland Press; Biochemical Society Transactions; 47; 6; 10-2019; 1815–1831
Compartir
Altmétricas
 
Estadísticas
Visualizaciones: 82
Descargas: 0

Enviar por e-mail
Separar cada destinatario (hasta 5) con punto y coma.
  • Facebook
  • Twitter
  • Instagram
  • YouTube
  • Sound Cloud

Los contenidos del CONICET están licenciados bajo Creative Commons Reconocimiento 2.5 Argentina License

Ministerio
https://www.conicet.gov.ar/ - CONICET

Inicio

Explorar

  • Autores
  • Disciplinas
  • Comunidades

Estadísticas

Novedades

  • Noticias
  • Boletines

Ayuda

Acerca de

  • CONICET Digital
  • Equipo
  • Red Federal

Contacto

Godoy Cruz 2290 (C1425FQB) CABA – República Argentina – Tel: +5411 4899-5400 repositorio@conicet.gov.ar
TÉRMINOS Y CONDICIONES