Capítulo de Libro
Reagents for the Covalent Attachment of mPEG to Peptides and Proteins
Título del libro: Handbook of Polymers for Pharmaceutical Technologies
Fecha de publicación:
2015
Editorial:
Wiley
ISBN:
978-1-119-04134-4
Idioma:
Inglés
Clasificación temática:
Resumen
In the last forty years, the conjugation of methoxy-poly(ethylene glycol) (mPEG) has evolved to become a well-established technology for the improvement of the physicochemical and therapeutic properties of biopharmaceutical peptides and proteins (PEGylation). In fact, eleven PEGylated products are available nowadays in the marketplace, while several others are under clinical evaluation. Ubiquitously present nucleophillic groups, such as the terminal -NH2 group, the ε-NH2 group of lysine and the -SH group of cysteine, have all been used to couple peptides and proteins to mPEG derivatives. Moreover, site-selective, reversible and enzymatic PEGylation have recently gained increasing attention among the biopharmaceutical community. Th e aim of this chapter is to summarize the most relevant and recent achievements obtained in the PEGylation of peptides and proteins, with an emphasis on the chemistry underlying the currently available methods for the preparation of mPEG reagents, as well as the chemistry involved in the PEGylation reactions.
Palabras clave:
PEGYLATION
,
PROTEIN CONJUGATION
,
ACTIVATED PEGS
,
BIOCONJUGATES
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Capítulos de libros de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Capítulos de libros de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Citación
Gonzalez, Marianela; Vaillard, Victoria Anahi; Vaillard, Santiago Eduardo; Reagents for the Covalent Attachment of mPEG to Peptides and Proteins; Wiley; 1; 2015; 63-123
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