Mathematical Modeling of Drug Delivery from Silicone Devices Used in Bovine Estrus Synchronization

Abstract

Bovine estrus synchronization is an important field for the veterinary pharmaceutical industry. A description of the natural bovine cycle and methods to cycle control are presented. In addition, commercially available silicone devices for bovine estrus synchronization are listed. The mathematical modeling of progestagens release from such devices is a crucial tool in the development of novel and/or optimized delivery systems. For this purpose, several in vitro models, approaches to explain the ADME processes and overall models are described. This type of mathematical modeling could help in the future to customize drug delivery systems to specific animals and/or situations.