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dc.contributor.author
Eslam, Mohammed
dc.contributor.author
Sanyal, Arun J.
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dc.contributor.author
George, Jacob
dc.contributor.author
Sookoian, Silvia Cristina
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dc.date.available
2020-07-23T15:26:14Z
dc.date.issued
2020-05
dc.identifier.citation
Eslam, Mohammed; Sanyal, Arun J.; George, Jacob; Sookoian, Silvia Cristina; MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease; W B Saunders Co-Elsevier Inc; Gastroenterology; 158; 7; 5-2020; 1999-2014.e1
dc.identifier.issn
0016-5085
dc.identifier.uri
http://hdl.handle.net/11336/110053
dc.description.abstract
Fatty liver associated with metabolic dysfunction is common, affects a quarter of the population, and has no approved drug therapy. Although pharmacotherapies are in development, response rates appear modest. The heterogeneous pathogenesis of metabolic fatty liver diseases and inaccuracies in terminology and definitions necessitate a reappraisal of nomenclature to inform clinical trial design and drug development. A group of experts sought to integrate current understanding of patient heterogeneity captured under the acronym nonalcoholic fatty liver disease (NAFLD) and provide suggestions on terminology that more accurately reflects pathogenesis and can help in patient stratification for management. Experts reached consensus that NAFLD does not reflect current knowledge, and metabolic (dysfunction) associated fatty liver disease "MAFLD" was suggested as a more appropriate overarching term. This opens the door for efforts from the research community to update the nomenclature and subphenotype the disease to accelerate the translational path to new treatments.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
W B Saunders Co-Elsevier Inc
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
NAFLD
dc.subject
MAFLD
dc.subject
NASH
dc.subject
METABOLIC SYNDROME
dc.subject.classification
Gastroenterología y Hepatología
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-05-07T14:21:50Z
dc.journal.volume
158
dc.journal.number
7
dc.journal.pagination
1999-2014.e1
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: Eslam, Mohammed. Westmead Hospital; Australia. University of Sydney; Australia
dc.description.fil
Fil: Sanyal, Arun J.. Virginia Commonwealth University. School of Medicine; Estados Unidos
dc.description.fil
Fil: George, Jacob. Westmead Hospital; Australia. University of Sydney; Australia
dc.description.fil
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.journal.title
Gastroenterology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1053/j.gastro.2019.11.312
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.gastrojournal.org/article/S0016-5085(20)30171-2/pdf
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