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dc.contributor.author
Cardoso, Estela M. del Luján
dc.contributor.author
Arregger, Alejandro Luis
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Ofner, Luis M.
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Estrada, Gabriela Margarita
dc.contributor.author
Goldberg, Victoria
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Contreras, Liliana Noemí
dc.date.available
2020-07-23T15:09:43Z
dc.date.issued
2003-11
dc.identifier.citation
Cardoso, Estela M. del Luján; Arregger, Alejandro Luis; Ofner, Luis M.; Estrada, Gabriela Margarita; Goldberg, Victoria; et al.; Spontaneous and cytokine induced natural killer cytotoxicity in patients with Cushing´s disease; Lippincott Williams; Endocrinologist; 13; 6; 11-2003; 459-464
dc.identifier.issn
1051-2144
dc.identifier.uri
http://hdl.handle.net/11336/110045
dc.description.abstract
Patients with endogenous hypercortisolism are prone to develop infectious diseases. In this study, we investigated the spontaneous and in vitro response to interleukin-2 (LAK) or interferon -a (IFN-a NK) natural killer cytotoxicity in 12 ambulatory female patients with Cushing’s disease (CD) Twelve healthy age-matched women served as control subjects (C). Mean spontaneous NK activity in CD ( 1.82 ± 0.77 LU/106 PBL) was not different than C (2.38 ± 0.59 LU/106 PBL). Mean LAK activity in CD (4.27 ± 1.72 LU/106 PBL) was significantly lower than C (9.52 ± 1.19 LU/10 6 PBL; p<0.001). Mean IFN-a NK cytotoxicity response in CD (3.33 ± 1.57 LU/10 6 PBL) was significantly reduced compared with C (8.41 ± 1.24 LU/106 PBL, p< 0.001). Spontaneous and stimulated NK cytotoxicity did not show correlation with plasma corticotrophin, total urinary-free cortisol or late salivary cortisol. Although spontaneous NK cytotoxicity did not demonstrate differences from healthy women, this finding did not exclude an impairment of the NK response to immunomodulators like found in these high-risk patients.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lippincott Williams
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Natural Killer
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CUSHING'S SYNDROME
dc.subject.classification
Medicina General e Interna
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Spontaneous and cytokine induced natural killer cytotoxicity in patients with Cushing´s disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-06-23T14:51:57Z
dc.journal.volume
13
dc.journal.number
6
dc.journal.pagination
459-464
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: Cardoso, Estela M. del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Arregger, Alejandro Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Ofner, Luis M.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Estrada, Gabriela Margarita. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Goldberg, Victoria. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.journal.title
Endocrinologist
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://insights.ovid.com/endocrinologist/endst/2003/11/000/spontaneous-cytokine-induced-natural-killer/6/00019616
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1097/01.ten.0000089861.71868.f2
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