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dc.contributor.author
Sosnik, Alejandro Dario
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Seremeta, Katia Pamela
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Imperiale, Julieta Celeste
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Chiappetta, Diego Andrés
dc.date.available
2020-07-20T15:09:10Z
dc.date.issued
2012-03
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Sosnik, Alejandro Dario; Seremeta, Katia Pamela; Imperiale, Julieta Celeste; Chiappetta, Diego Andrés; Novel formulation and drug delivery strategies for the treatment of pediatric poverty-related diseases; Informa Healthcare; Expert Opinion on Drug Delivery; 9; 3-2012; 303-323
dc.identifier.issn
1742-5247
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http://hdl.handle.net/11336/109649
dc.description.abstract
INTRODUCTION: Due to a lack of approved drugs and formulations, children represent the most vulnerable patients. Magistral, unlicensed formulations obtained by the manipulation of solid forms should undergo clinical evaluation to ensure bioequivalence. The development of new pediatric medicines is complex and faces technological, economic and ethical challenges. This phenomenon has contributed to the emergence of an adult-children gap. To improve the situation, the World Health Organization launched the global campaign ´Make medicines child size´ and a number of international initiatives have been established. The situation is more critical in the case of poverty-related diseases (PRDs) that mainly affect poor countries. AREAS COVERED: This review critically discusses different strategies to develop pediatric formulations and drug delivery systems (DDS) in PRDs and their potential implementation in the current market. Readers will gain an updated perspective on the development of pediatric medicines for the treatment of PRDs and the proximate challenges and opportunities faced to ensure an effective pharmacotherapy. EXPERT OPINION: There is an urgent need for the development of innovative, scalable and cost-viable formulations to ensure pediatric patients have access to appropriate medications for PRDs. The guidelines of the International Conference on Harmonisation constitute a very good orientation tool, as they emphasize physiological and developmental aspects that need to be considered in pediatric research. It is important to consider cultural, economic and ethical aspects that make developing nations facing PRDs different from the developed world. Thus, the best strategy would probably be to conceive and engage similar initiatives in the developing world, to address unattended therapeutic niches.
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application/pdf
dc.language.iso
eng
dc.publisher
Informa Healthcare
dc.rights
info:eu-repo/semantics/openAccess
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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PEDIATRIC DRUG DELIVERY AND FORMULATIONS
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PHARMACOTHERAPY OF POVERTY-RELATED DISEASES
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Nano-materiales
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Nanotecnología
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Novel formulation and drug delivery strategies for the treatment of pediatric poverty-related diseases
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
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info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-05-11T18:16:12Z
dc.journal.volume
9
dc.journal.pagination
303-323
dc.journal.pais
Reino Unido
dc.journal.ciudad
London
dc.description.fil
Fil: Sosnik, Alejandro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina
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Fil: Seremeta, Katia Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina
dc.description.fil
Fil: Imperiale, Julieta Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina
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Fil: Chiappetta, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina
dc.journal.title
Expert Opinion on Drug Delivery
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://informahealthcare.com/doi/abs/10.1517/17425247.2012.655268
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info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1517/17425247.2012.655268
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