Artículo
Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur
Mussin, Javier Esteban
; Roldan, Maria Virginia
; Rojas, Florencia Dinorah
; Sosa, Maria de Los Angeles; Pellegri, Nora Susana
; Giusiano, Gustavo Emilio
Fecha de publicación:
08/2019
Editorial:
Springer
Revista:
Applied Microbiology and Biotechnology
ISSN:
2191-0855
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Malassezia furfur is lipophilic and lipid-dependent yeast, inhabitant of human skin microbiota associated with several dermal disorders. In recent years, along with the advances in nanotechnology and the incentive to find new antimicrobialdrugs, there has been a growing interest in the utilization of nanoparticles for the treatment of skin microbial infections. This work aimed to study the in vitro inhibitory activity of silver nanoparticles (AgNP) against 41 M. furfurclinical isolates, visualize the interaction between AgNP-Malassezia, evaluate the synergism with ketoconazole (KTZ) and to produce an antimicrobial gel of AgNP?KTZ. The synthesized AgNP were randomly distributed around the yeastsurface and showed a fungicidal action with low minimal inhibitory concentration values. AgNP showed no antagonistic effect with KTZ. The broad-spectrum antimicrobial property with fungicidal action of AgNP and its accumulationin affected areas with a sustained release profile, added to the great antifungal activity of KTZ against Malassezia infections and other superficial mycoses, allowed us to obtain a gel based on carbopol formulated with AgNP?KTZwith the potential to improve the topical therapy of superficial malasseziosis, reduce the number of applications and, also, prevent the recurrence.
Palabras clave:
MALASSEZIA
,
NANOPARTICLES
,
ANTIFUNGAL ACTIVITY
,
SYNERGY
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CCT - NORDESTE)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - NORDESTE
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - NORDESTE
Articulos(IFIR)
Articulos de INST.DE FISICA DE ROSARIO (I)
Articulos de INST.DE FISICA DE ROSARIO (I)
Citación
Mussin, Javier Esteban; Roldan, Maria Virginia; Rojas, Florencia Dinorah; Sosa, Maria de Los Angeles; Pellegri, Nora Susana; et al.; Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur; Springer; Applied Microbiology and Biotechnology; 9; 131; 8-2019; 1-9
Compartir
Altmétricas