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dc.contributor.author
Pérez Iglesias, Juan Manuel
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Franco Belussi, Lilian
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Natale, Guillermo Sebastian
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Oliveira, Classius de
dc.date.available
2020-07-16T19:34:41Z
dc.date.issued
2019-01
dc.identifier.citation
Pérez Iglesias, Juan Manuel; Franco Belussi, Lilian; Natale, Guillermo Sebastian; Oliveira, Classius de; Biomarkers at different levels of organisation after atrazine formulation (SIPTRAN 500SC®) exposure in Rhinella schineideri (Anura: Bufonidae) Neotropical tadpoles; Elsevier; Environmental Pollution; 244; 1-2019; 733-746
dc.identifier.issn
0269-7491
dc.identifier.uri
http://hdl.handle.net/11336/109471
dc.description.abstract
Brazil is an important consumer of herbicides. In sugarcane cultivation?the country´s most extensive agricultural crop?atrazine-based formulations are the principal form of weed control. Several studies have investigated adverse effects of atrazine or their formulations on anurans, but not specifically on Brazilian species. Our aim was therefore to investigate the lethal and sublethal effects of an atrazine-based herbicide in Rhinella schneideri tadpoles and, in particular, effects on the pigmentation system as a new endpoint in ecotoxicological studies. Rhinella schneideri tadpoles at the Gosner-30 stage were exposed to the atrazine-based herbicide formulation, SIPTRAN 500 SC®, in acute bioassays at concentrations of 1.5?25 mg/L. The lethal and sublethal effects induced were analysed at different ecotoxicological levels: organismal level (alterations in behaviour, growth, development, and body mass; morphologic abnormalities), histological level (liver histopathology), the pigmentation system (melanomacrophages and dermal-melanophores), and cellular level (erythrocyte micronucleus formation and other nuclear-abnormalities). This herbicide induced sublethal effects at the organismal level with alterations in swimming and growth and morphologic abnormalities. These results demonstrated that, in anuran tadpoles, the atrazine-based agrochemical increased the frequency of micronucleus formation and other nuclear-abnormalities in erythrocytes and caused liver damage. In addition, we demonstrated for the first time effects of an atrazine-based formulation on the pigmentation system of anuran tadpoles, specifically an increase in the number of melanomacrophages and dermal melanophores. This study is the first to use several widely differing endpoints at different ecotoxicological levels in a comprehensive manner for assessment of the effects of environmental stressors in order to determine the health status of Neotropical anuran species. In doing so, this study establishes a foundation for future ecological assessments. Atrazine-based formulation promotes deleterious effects at different ecotoxicological levels in Neotropical anuran involving hepato- and cytotoxicity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ATRAZINE FORMULATION
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ENDPOINTS
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INTEGRATIVE RESPONSES
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NEOTROPICAL TADPOLES
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PIGMENTARY SYSTEM
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RHINELLA SCHNEIDERI
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Otras Ciencias de la Tierra y relacionadas con el Medio Ambiente
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Ciencias de la Tierra y relacionadas con el Medio Ambiente
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CIENCIAS NATURALES Y EXACTAS
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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Ecología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Biomarkers at different levels of organisation after atrazine formulation (SIPTRAN 500SC®) exposure in Rhinella schineideri (Anura: Bufonidae) Neotropical tadpoles
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-04-23T19:26:19Z
dc.journal.volume
244
dc.journal.pagination
733-746
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Pérez Iglesias, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
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Fil: Franco Belussi, Lilian. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
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Fil: Natale, Guillermo Sebastian. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
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Fil: Oliveira, Classius de. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.journal.title
Environmental Pollution
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.envpol.2018.10.073
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0269749118303282
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