Artículo
Association of common variants in JAK2 gene with reduced risk of Metabolic Syndrome and related disorders
Penas Steinhardt, Alberto
; Tellechea, Mariana Lorena
; Gomez Rosso, Leonardo Adrián
; Brites, Fernando Daniel
; Frechtel, Gustavo Daniel; Poskus, Edgardo
Fecha de publicación:
11/2011
Editorial:
BioMed Central
Revista:
BMC Medical Genetics
ISSN:
1471-2350
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background: Disturbances in leptin and insulin signaling pathways are related to obesity and metabolic syndrome (MS) with increased risk of diabetes and cardiovascular disease. Janus kinase 2 (JAK2) is a tyrosine kinase involved in the activation of mechanisms that mediate leptin and insulin actions. We conducted a population cross-sectional study to explore the association between two common variants in JAK2 gene and MS related traits in 724 Argentinean healthy male subjects. Methods A total of 724 unrelated men aged 37.11 ± 10.91 yr were included in a cross-sectional study. Physical examination, anthropometric measurements and biochemical analysis were determined by a standardized protocol. rs7849191 and rs3780378 were genotyped. Analyses were done separately for each SNP and followed up by haplotype analysis. Results rs7849191 and rs3780378 were both associated with reduced risk of MS [p = 0.005; OR (95%CI) = 0.52 (0.33-0.80) and p = 0.006; OR (95% CI) = 0.59 (0.40-0.86) respectively, assuming a dominant model]. rs3780378 T allele was associated with triglyceridemia values under 150 mg/dl [p = 0.007; OR (95%CI) = 0.610 (0.429-0.868)] and TT carriers showed lower triglycerides (p = 0.017), triglycerides/HDL-C ratio (p = 0.022) and lipid accumulation product (p = 0.007) compared to allele C carriers. The two-SNPs-haplotype analysis was consistent with single locus analysis. Conclusions It was found for the first time, significant associations of JAK2 common variants and related haplotypes with reduced risk of MS. These findings could be explained by the role of JAK2 in insulin and/or leptin signaling.
Palabras clave:
METABOLIC SYNDROME
,
JAK2
,
POLIMORPHISMS
,
DIABETES
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Penas Steinhardt, Alberto; Tellechea, Mariana Lorena; Gomez Rosso, Leonardo Adrián; Brites, Fernando Daniel; Frechtel, Gustavo Daniel; et al.; Association of common variants in JAK2 gene with reduced risk of Metabolic Syndrome and related disorders; BioMed Central; BMC Medical Genetics; 12; 11-2011; 166-171
Compartir
Altmétricas