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dc.contributor.author
Casanova, Natalia Andrea
dc.contributor.author
Ariagno, Julia Irene
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López Nigro, Marcela Mabel
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Mendeluk, Gabriela Ruth
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Gette, Maria de Los Angeles
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Petenatti, Elisa Margarita
dc.contributor.author
Palaoro, Luis Alberto
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Carballo, Marta Ana
dc.date.available
2020-07-14T18:53:57Z
dc.date.issued
2013-09
dc.identifier.citation
Casanova, Natalia Andrea; Ariagno, Julia Irene; López Nigro, Marcela Mabel; Mendeluk, Gabriela Ruth; Gette, Maria de Los Angeles; et al.; In vivo antigenotoxic activity of watercress juice (Nasturtium officinale) against induced DNA damage; John Wiley & Sons Ltd; Journal of Applied Toxicology; 33; 9; 9-2013; 880-885
dc.identifier.issn
0260-437X
dc.identifier.uri
http://hdl.handle.net/11336/109256
dc.description.abstract
The present study was carried out to investigate the genotoxicity as well as possible protective activity against damage induced by cyclophosphamide (CP) of the aqueous juice of watercress (Nasturtium officinale, W.T. Aiton) in vivo. Male and female Swiss mice 7-8 weeks old (N = 48) were treated by gavage with 1 g kg(-1) body weight and 0.5 g kg(-1) body weight of watercress juice during 15 consecutive days. Genotoxicity and its possible protective effect were tested by the comet assay in peripheral blood cells and the micronucleus test in bone marrow. In addition, biopsies of the bladder, epididymis and testicles of mice were performed to extend the experimental design. Watercress juice per se did not induce genetic damage according to the comet assay and micronucleus study, exhibiting a protective activity against CP (P < 0.05 and P < 0.001, respectively). The comparative analysis of bladder histological changes obtained in the watercress plus CP group against those treated with CP alone suggests a probable protective effect. Further studies are needed in order to establish the protective role of watercress juice against DNA damage.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
antigenotoxicity
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biomarkers
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bladder
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cyclophosphamide
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Toxicología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
In vivo antigenotoxic activity of watercress juice (Nasturtium officinale) against induced DNA damage
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-05-11T18:11:49Z
dc.journal.volume
33
dc.journal.number
9
dc.journal.pagination
880-885
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Casanova, Natalia Andrea. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Instituto Nacional de Tecnología Agropecuaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Ariagno, Julia Irene. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
dc.description.fil
Fil: López Nigro, Marcela Mabel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
dc.description.fil
Fil: Mendeluk, Gabriela Ruth. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
dc.description.fil
Fil: Gette, Maria de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad Nacional de San Luis; Argentina
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Fil: Petenatti, Elisa Margarita. Universidad Nacional de San Luis; Argentina
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Fil: Palaoro, Luis Alberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
dc.description.fil
Fil: Carballo, Marta Ana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
dc.journal.title
Journal of Applied Toxicology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/jat.2746
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jat.2746
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