Mostrar el registro sencillo del ítem
dc.contributor.author
Storer, Cheryl L.
dc.contributor.author
Dickey, Chad A.
dc.contributor.author
Galigniana, Mario Daniel
dc.contributor.author
Rein, Theo
dc.contributor.author
Cox, Marc B.
dc.date.available
2017-01-05T20:23:44Z
dc.date.issued
2011-12
dc.identifier.citation
Storer, Cheryl L.; Dickey, Chad A.; Galigniana, Mario Daniel; Rein, Theo; Cox, Marc B.; FKBP51 and FKBP52 in signaling and disease; Elsevier; Trends In Endocrinology And Metabolism; 22; 12; 12-2011; 481-490
dc.identifier.issn
1043-2760
dc.identifier.uri
http://hdl.handle.net/11336/10888
dc.description.abstract
FKBP51 and FKBP52 are diverse regulators of steroid hormone receptor signaling, including receptor maturation, hormone binding and nuclear translocation. Although structurally similar, they are functionally divergent, which is largely attributed to differences in the FK1 domain and the proline-rich loop. FKBP51 and FKBP52 have emerged as likely contributors to a variety of hormone-dependent diseases, including stress-related diseases, immune function, reproductive functions and a variety of cancers. In addition, recent studies have implicated FKBP51 and FKBP52 in Alzheimer's disease and other protein aggregation disorders. This review summarizes our current understanding of FKBP51 and FKBP52 interactions within the receptor-chaperone complex, their contributions to health and disease, and their potential as therapeutic targets for the treatment of these diseases.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Molecular Chaperones
dc.subject
Alzheimer Disease
dc.subject
Hsp90
dc.subject
Recpetors
dc.subject
Steroid
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
FKBP51 and FKBP52 in signaling and disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-12-30T13:43:00Z
dc.journal.volume
22
dc.journal.number
12
dc.journal.pagination
481-490
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Storer, Cheryl L.. University Of Texas At El Paso; Estados Unidos
dc.description.fil
Fil: Dickey, Chad A.. University of South Florida. Alzheimer’s Institute; Estados Unidos
dc.description.fil
Fil: Galigniana, Mario Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
dc.description.fil
Fil: Rein, Theo. Max Planck Institute of Psychiatry; Alemania
dc.description.fil
Fil: Cox, Marc B.. University Of Texas At El Paso; Estados Unidos
dc.journal.title
Trends In Endocrinology And Metabolism
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(11)00119-6
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.tem.2011.08.001
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1043276011001196
Archivos asociados