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dc.contributor.author
Fuertes, Mercedes Beatriz
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dc.contributor.author
Kacha, Aalok K.
dc.contributor.author
Kline, Justin
dc.contributor.author
Woo, Seng Ryong
dc.contributor.author
Kranz, David M.
dc.contributor.author
Murphy, Kenneth M.
dc.contributor.author
Gajewski, Thomas F.
dc.date.available
2017-01-05T20:17:56Z
dc.date.issued
2011-09
dc.identifier.citation
Fuertes, Mercedes Beatriz; Kacha, Aalok K. ; Kline, Justin ; Woo, Seng Ryong ; Kranz, David M. ; et al.; Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8alpha+ dendritic cells; Rockefeller Univ Press; Journal Of Experimental Medicine; 208; 10; 9-2011; 2005-2016
dc.identifier.issn
0022-1007
dc.identifier.uri
http://hdl.handle.net/11336/10886
dc.description.abstract
Despite lack of tumor control in many models, spontaneous T cell priming occurs frequently in response to a growing tumor. However, the innate immune mechanisms that promote natural antitumor T cell responses are undefined. In human metastatic melanoma, there was a correlation between a type I interferon (IFN) transcriptional profile and T cell markers in metastatic tumor tissue. In mice, IFN-b was produced by CD11c(+) cells after tumor implantation, and tumor-induced T cell priming was defective in mice lacking IFN-a/bR or Stat1. IFN signaling was required in the hematopoietic compartment at the level of host antigen-presenting cells, and selectively for intratumoral accumulation of CD8a(+) dendritic cells, which were demonstrated to be essential using Batf3(-/-) mice. Thus, host type I IFNs are critical for the innate immune recognition of a growing tumor through signaling on CD8alfa(+) DCs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Rockefeller Univ Press
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Interferon
dc.subject
Tumor
dc.subject
Cd8 T Cell
dc.subject
Dendritic Cell
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8alpha+ dendritic cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-12-30T13:42:57Z
dc.identifier.eissn
1540-9538
dc.journal.volume
208
dc.journal.number
10
dc.journal.pagination
2005-2016
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Birmingham, Alabama
dc.description.fil
Fil: Fuertes, Mercedes Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University Of Chicago; Estados Unidos
dc.description.fil
Fil: Kacha, Aalok K. . University Of Chicago; Estados Unidos
dc.description.fil
Fil: Kline, Justin . University Of Chicago; Estados Unidos
dc.description.fil
Fil: Woo, Seng Ryong . University Of Chicago; Estados Unidos
dc.description.fil
Fil: Kranz, David M. . University Of Illinois; Estados Unidos
dc.description.fil
Fil: Murphy, Kenneth M. . Washington University in St. Louis; Estados Unidos
dc.description.fil
Fil: Gajewski, Thomas F. . University Of Chicago; Estados Unidos
dc.journal.title
Journal Of Experimental Medicine
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://jem.rupress.org/content/208/10/2005
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http:/dx.doi.org/10.1084/jem.20101159
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