Artículo
Hepatitis B surface antibodies seroprevalence among people born before and after implementation of universal HBV vaccination
Di Lello, Federico Alejandro
; Blejer, Jorgelina L.; Alter, Adriana; Bartoli, Sonia; Vargas, Fabiana Alejandra; Ruiz, Rosángela; Galli, Claudio; Blanco, Sebastian; Gallego, Sandra Veronica
; Fernández, Roberto; Martínez, Alfredo P.; Flichman, Diego Martin
Fecha de publicación:
03/2020
Editorial:
Elsevier
Revista:
Vaccine
ISSN:
0264-410X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Universal vaccination is the most effective strategy to control hepatitis B virus (HBV) infection. In Argentina, vaccination against HBV was incorporated in year 2000 for newborns and in 2003 for 11 years old children. However, there is a paucity of data about protection levels against HBV infection. The aim of this work was to determine the prevalence of seroprotective anti-HBs antibodies (aHBs) in Argentina. Serum samples negative for HBsAg and anti-HBc from 132 children born after year 2000 and 762 blood donors, older than 18 years, from five centers across the country, were analyzed for aHBs. Titers ¡Ý10 mIU/mL were observed in 74/132 children (56.1%) and 336/762 (44.1%) in blood donors. The median age for blood donors was 33.9 (23¨C43); from them, 210 (27.6%) were born after 1992 and, therefore, were catch-up by vaccine implementation at 11 years old age. Donors born in 1992 or before showed a significantly lower frequency of protection (32.2%) compared to donors born after 1992 (75.2%), p < 0.0001. In addition, significant differences were observed in the status of seroprotection between different participating centers (p = 0.024). Implementation of HBV vaccine in 2000 and 2003 implied an overall increase of the aHBs seroprotective rates, with a particularly adequate response in children vaccinated at 11 years old age. The observed results suggest that population born in 1992 or before is currently the most susceptible. Consequently, it would be advisable to become aware of the risk of transmission in this age group and to stress this population vaccination campaigns.
Palabras clave:
ANTI-HBS TITERS
,
HEPATITIS B VIRUS
,
VACCINE
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Identificadores
Colecciones
Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Di Lello, Federico Alejandro; Blejer, Jorgelina L.; Alter, Adriana; Bartoli, Sonia; Vargas, Fabiana Alejandra; et al.; Hepatitis B surface antibodies seroprevalence among people born before and after implementation of universal HBV vaccination; Elsevier; Vaccine; 38; 12; 3-2020; 2678-2682
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