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dc.contributor.author
Cruces, Pablo Daniel  
dc.contributor.author
Torkar, Drago  
dc.contributor.author
Arini, Pedro David  
dc.date.available
2020-06-30T20:35:19Z  
dc.date.issued
2020-05  
dc.identifier.citation
Cruces, Pablo Daniel; Torkar, Drago; Arini, Pedro David; Biomarkers of pre-existing risk of Torsade de Pointes under Sotalol treatment; Elsevier; Journal of Electrocardiology; 60; 5-2020; 177-183  
dc.identifier.issn
0022-0736  
dc.identifier.uri
http://hdl.handle.net/11336/108545  
dc.description.abstract
Introduction: Antiarrhythmic drugs therapies are currently going through a turning point. The high risk that exists during the treatments has led to an ongoing search for new non-invasive toxicity risk biomarkers. Methods: We propose the use of spatial biomarkers obtained through the quaternion algebra, evaluating the dynamics of the cardiac electrical vector in a non-invasive way in order to detect abnormal changes in ventricular heterogeneity. In groups of patients with and without history of Torsade de Pointes undergoing a Sotalol challenge, we compute the radius and the linear and angular velocities of QRS complex and T-wave loops. From these signals we extract significant features in order to compute a risk patient classifier. Results: Using machine learning techniques and statistical analysis, the combinations of few indices reach a pair of sensitivity/specificity of 100%/100% when separating patients with arrhythmogenic substrate. Several biomarkers not only measure drug-induced changes significantly but also observe differences in at-risk patients outperforming current standards. Discussion: Alternative biomarkers were able to describe pre-existing risk of patients. Given the high levels of significance and performance, these results could contribute to a better understanding of the torsadogenic substrate and to the safe development of drug therapies.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
CARDIAC ELECTRICAL VECTOR  
dc.subject
ANTIARRHYTMIC DRUGS  
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PROARRHYTHMIC SIDE EFFECTS  
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QUATERNION THEORY  
dc.subject.classification
Otras Ingeniería Eléctrica, Ingeniería Electrónica e Ingeniería de la Información  
dc.subject.classification
Ingeniería Eléctrica, Ingeniería Electrónica e Ingeniería de la Información  
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INGENIERÍAS Y TECNOLOGÍAS  
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Farmacología y Farmacia  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Biomarkers of pre-existing risk of Torsade de Pointes under Sotalol treatment  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-06-23T15:10:19Z  
dc.journal.volume
60  
dc.journal.pagination
177-183  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Cruces, Pablo Daniel. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Ingeniería Biomédica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderón; Argentina  
dc.description.fil
Fil: Torkar, Drago. Institut Jožef Stefan; Eslovenia  
dc.description.fil
Fil: Arini, Pedro David. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderón; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Ingeniería Biomédica; Argentina  
dc.journal.title
Journal of Electrocardiology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0022073620301308  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jelectrocard.2020.04.011